TNFalpha has been proposed to underlie synaptic scaling, but the mechanism and functional significance of this remain unclear. In this issue of Neuron, Cingolani et al. demonstrate that TNFalpha can mediate scaling through the regulation of beta3 integrins. Kaneko et al. show that TNFalpha-dependent synaptic scaling plays an important role in visual cortical plasticity.
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| http://dx.doi.org/10.1016/j.neuron.2008.05.017 | DOI Listing |
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