AI Article Synopsis
- Researchers developed a simple one-step method to create various alpha,alpha-disubstituted 2-pyrrolidinylmethanols using ketones and SmI2 as a catalyst with 1-pyrroline N-oxide.
- The process is efficient and highlights the effectiveness of SmI2-mediated cross-coupling in organic synthesis.
- Additionally, the study includes the preparation and resolution of N-hydroxy-alpha,alpha-diphenylprolinol, showcasing its potential applications.
Article Abstract
Various alpha,alpha-disubstituted 2-pyrrolidinylmethanols are efficiently prepared in a single step from ketones using a SmI2-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-alpha,alpha-diphenylprolinol is also easily prepared and resolved.
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| http://dx.doi.org/10.1021/ol800982n | DOI Listing |
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