Dr Erasmus Darwin (1731-1802) readily acknowledged that diseases including gout, consumption, scrofula, epilepsy, and insanity were hereditarily transferred. He also viewed a particular interconnectedness between intemperance (alcoholism) and other hereditary diseases. Darwin's view of 'hereditary' incorporated a malleable admixture of nature and nurture causes. Consistent with his deistic beliefs that development on the Earth followed no fixed plan, Darwin argued that hereditary diseases were not predestined. To overcome or prevent disease, Darwin argued that one must learn how best to exert power over nature and to improve nurture.
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Pharmacoepidemiol Drug Saf
November 2024
Pharmaco- and Device Epidemiology, Centre for Statistics in Medicines, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Purpose: The generation of representative disease phenotypes is important for ensuring the reliability of the findings of observational studies. The aim of this manuscript is to outline a reproducible framework for reliable and traceable phenotype generation based on real world data for use in the Data Analysis and Real-World Interrogation Network (DARWIN EU). We illustrate the use of this framework by generating phenotypes for two diseases: pancreatic cancer and systemic lupus erythematosus (SLE).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Introduction: Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms.
Methods: We included 207 pre-symptomatic genetic mutation carriers and 188 relatives without mutations.
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