Amphibian metamorphosis is an excellent model to study the diverse effects of thyroid hormones (TH). TH modulate target gene expression via thyroid hormone receptors (TR). Generally, unliganded TR repress transcription, whereas liganded TR activate transcription. During metamorphosis, these dual effects of TR are evident. Moreover, we show that gene specific response to TH can underline the multiple effects of TH. Finally, studies of unliganded-thyroid hormone receptor function reveal a physiological role in eye development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1051/jbio:2008009 | DOI Listing |
Publication Analysis
Top Keywords
thyroid hormone
8
[mechanisms underlying
4
underlying thyroid
4
hormone response
4
response gene
4
gene regulation
4
regulation amphibian
4
amphibian development]
4
development] amphibian
4
amphibian metamorphosis
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!