A palpable abnormality of the breast was found in three women, one aged 57 and two aged 41. The first two patients predominantly showed the characteristics of a purulent inflammation, and on mammogram the third patient appeared to have mastitis carcinomatosa. Histopathological investigation revealed a lobular, non-caseating granulomatous inflammation. They were treated with prednisone and the first and third patients also received azathioprine. After some time, the condition recurred in the contralateral breast in the second and third patients. Once again, medicinal treatment was given. When a palpable tumour of the breast is found the primary goal is to exclude malignancy. Granulomatous lobular mastitis is a rare and benign tumour of the breast that clinically mimics carcinoma. Often, conventional imaging does not lead to the diagnosis. A histological needle biopsy is the best way to reach a diagnosis. Immunosuppressive therapy is effective and is preferred over surgery.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Infections Due to Corynebacterium kroppenstedtii With Focus on Granulomatous Lobular Mastitis for Tissue Specificity, Pathogenesis, Bacteriologic Workup, and Treatment.
Arch Pathol Lab Med
January 2025
From the Divisions of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas (Gan, Y Ding, Wu, Zhang, Meng, QQ Ding, Han).
Objective.—: To report the isolation and significance of C kroppenstedtii, features of patients with GLM, pathologic findings and mechanism, bacteriologic workup, and optimal treatment.
Design.
Cystic Neutrophilic Granulomatous Mastitis: Imaging Features With Histopathologic Correlation.
J Breast Imaging
December 2024
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Cystic neutrophilic granulomatous mastitis (CNGM) is a rare type of granulomatous lobular mastitis (GLM) with a distinct histologic pattern characterized on histopathology by clear lipid vacuoles lined by peripheral neutrophils ("suppurative lipogranulomas"), often containing gram-positive bacilli and strongly associated with Corynebacterial infection (in particular, Corynebacterium kroppenstedtii). Cystic neutrophilic granulomatous mastitis has a distinct histopathologic appearance, but the imaging appearance is less well described and has been limited to case reports and small case series published primarily in pathology literature. Mammographic findings of CNGM include focal asymmetry, skin thickening, and irregular or oval masses.
View Article and Find Full Text PDFConcurrence of idiopathic granulomatous mastitis and breast cancer in a patient on neoadjuvant chemotherapy: A case report.
Int J Surg Case Rep
January 2025
Associate Professor, Department of Breast Surgery, Aga Khan University Hospital, Karachi, Pakistan. Electronic address:
Article Synopsis
- Idiopathic Granulomatous Mastitis (IGM) is a rare benign inflammatory condition affecting the breast, often challenging to diagnose.
- A case study highlights a 45-year-old woman who developed IGM after neoadjuvant chemotherapy for stage II invasive ductal carcinoma, eventually requiring modified radical mastectomy and steroid treatment.
- There is limited literature on IGM, and existing treatment guidelines are not well-established, complicating management approaches.
Imaging manifestations and treatment efficacy of Granulomatous Lobular Mastitis: An analysis of 29 cases with internal and external traditional Chinese medicine approaches.
Pak J Med Sci
November 2024
Chunzhi Li, Department of Radiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China.
Article Synopsis
- The study investigated the effects of traditional Chinese medicine (TCM) on granulomatous lobular mastitis (GLM) using MRI to assess changes in clinical manifestations before and after treatment.
- Results showed significant reductions in symptoms like lumps, pain, and menstrual irregularities among the 29 women studied, confirming the effectiveness of TCM.
- MRI findings revealed notable changes in lesion characteristics and other clinical features, indicating that TCM therapy can provide reliable improvements for patients with GLM.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!