AI Article Synopsis
- Entacapone (EN) enhances the effect of levodopa/dopa decarboxylase inhibitors (LD/DDI) by blocking the enzyme COMT, which helps in producing basic metabolites of levodopa.
- In a study, parkinsonian patients showed a higher recovery rate of (13)C-sodium-octanoate when taking a combination of levodopa, Carbidopa (CD), and Entacapone (EN) compared to only levodopa and CD.
- The inhibition of COMT creates a more favorable (basic) environment in the gastrointestinal tract, improving the absorption of acids and salts, which may also lead to better absorption of levodopa itself.
Article Abstract
Entacapone (EN) improves the efficacy of levodopa/dopadecarboxylase inhibitor (LD/DDI) formulations by inhibition of the enzyme catechol-O-methyltransferase (COMT). COMT inhibition also promotes the synthesis of basic LD metabolites, whereas DDI support the composition of acidic LD derivatives. LD metabolism correlates to the one of (13)C-sodium-octanoate, which is employed in breath tests to measure gastric emptying velocity. Objectives were to investigate the impact of COMT inhibition on the recovery rate of (13)C-sodium-octanoate in parkinsonian patients, who received first 100 mg LD/Carbidopa (CD) and the next day 100 mg LD/CD/EN combined with (13)C-sodium-octanoate in each case. The recovery rate of (13)C-sodium-octanoate was significant higher during the LD/CD/EN-compared with the LD/CD condition. COMT inhibition combined with LD/DDI improves absorption of a co-administered salt probably due to a COMT inhibition induced basic environment in gastrointestinal membranes. This improves dissolution and absorption of acids and salts. Thus it may enhance absorption of LD itself.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mds.22176 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative response mechanisms of two cultivars of to f.sp. infection.
Front Plant Sci
January 2025
Fruit Tree Center, Tropical Crops Genetic Resources Institute of Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
With the aim of enhancing plants' ability to respond to pathogenic fungi, this study focuses on disease resistance genes. We commenced a series of investigations by capitalizing on the pronounced differences in resistance to Fusarium wilt between resistant and susceptible varieties. Through an in-depth exploration of the metabolic pathways that bolster this defense, we identified genes associated with resistance to f.
View Article and Find Full Text PDFInhibition of mPFC norepinephrine improved chronic post-thoracotomy pain in adult rats.
Ann Med
December 2025
Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Background: Chronic post-thoracotomy pain (CPTP) is characterized by high incidence, long duration, and severity of pain. Medial prefrontal cortex (mPFC) is a brain region closely associated with chronic pain, and norepinephrine is involved in pain regulation. But the role of mPFC norepinephrine in CPTP and its possible mechanism is unclear.
View Article and Find Full Text PDFThe Critical Role of Phenylpropanoid Biosynthesis Pathway in Lily Resistance Against Gray Mold.
Int J Mol Sci
October 2024
Laboratory of Flower Bulbs, Department of Landscape Architecture, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Gray mold caused by is one of the most determinative factors of lily growth and has become a major threat to lily productivity. However, the nature of the lily interaction remains largely unknown. Here, comparative transcriptomic and metabolomic were used to investigate the defense responses of resistant ('Sorbonne') and susceptible ('Tresor') lily cultivars to infection at 24 hpi.
View Article and Find Full Text PDFExploring Nanocarriers for Boosting Entacapone Bioavailability: A Journey through System Characterization and Assessment of Toxicity and Pharmacological and 2D Permeability Paybacks.
ACS Appl Mater Interfaces
October 2024
CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
Catechol--methyltransferase inhibitors (iCOMT), such as entacapone, have been successfully employed to treat tremor-related symptoms of Parkinson's disease. However, iCOMT has been associated with a short half-life and poor oral bioavailability. Nanobased drug delivery systems have often been used to overcome this type of setbacks.
View Article and Find Full Text PDFLevodopa / opicapone as a complement to STN-DBS in clinical practice. A retrospective single-centre analysis.
eNeurologicalSci
December 2024
Centre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany.
Objective: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a well-established treatment option in Parkinson's disease with motor and non-motor fluctuations allowing for postoperative reduction of dopaminergic medication. However, evidence is scarce on optimal medication adjustments following STN-DBS implantation. Opicapone allows for long-lasting inhibition of the catechol--methyltransferase (COMT) thereby enabling more constant dopaminergic stimulation compared to levodopa alone.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!