To evaluate the feasibility of two kinds of pterin derivatives, 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1254/jphs.08002sc | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Photostability and photodynamic antimicrobial profile of dye extracts from four (4) plants: prospects for eco-friendly low-cost food disinfection and topical biomedical applications.
Photochem Photobiol Sci
June 2024
Faculty of Chemistry, Center for Nanointegration Duisburg‑Essen and Centre for Water and Environmental Research, University of Duisburg-Essen, Duisburg, Germany.
In this study, photostability and photodynamic antimicrobial performance of dye extracts from Hibiscus sabdariffa (HS) calyces, Sorghum bicolor (SB) leaf sheaths, Lawsonia inermis (LI) leaves and Curcuma longa (CL) roots were investigated in Acetate-HCl (AH) Buffer (pH 4.6), Tris Base-HCl (TBH) Buffer (pH 8.6), distilled water (dHO), and Phosphate Buffer Saline (PBS, pH 7.
View Article and Find Full Text PDFPorphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents.
Sci Rep
May 2024
Department of Chemistry, Assam University, Silchar, Assam, 788011, India.
A series of 4-carboxyphenyl/4-hydroxyphenyl meso-substituted porphyrins were synthesized, purified, and characterized. The compounds exhibited anti-HIV-1 activities, in vitro, under both non-photodynamic (non-PDT) and photodynamic (PDT) conditions. Specifically, the porphyrins inhibited HIV-1 virus entry, with c-PB(OH) and PB(OH) showing significant anti-HIV-1 activity.
View Article and Find Full Text PDFEvaluation of carboxylic acid-derivatized corroles as novel gram-positive antibacterial agents under non-photodynamic inactivation conditions.
Bioorg Med Chem Lett
February 2023
Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB, UMR CNRS 6302), Université Bourgogne Franche-Comté, 9 avenue Alain Savary, BP 47870, 21078 Dijon Cedex, France. Electronic address:
Herein, we report the synthesis and evaluation of carboxylic acid corroles bearing either one, two, three of four carboxylic groups as gram-positive antibacterial agents against two strains of S. aureus, one methicillin-sensible (MSSA) and the other methicillin-resistant (MRSA). Lead compounds 5 and 6 show low minimum inhibitory concentrations (MICs) of 0.
View Article and Find Full Text PDFTwo cationic meso-thiophenium porphyrins and their zinc-complexes as anti-HIV-1 and antibacterial agents under non-photodynamic therapy (PDT) conditions.
Bioorg Med Chem Lett
June 2022
Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India. Electronic address:
The anti-HIV-1 and antimicrobial activities of novel cationic meso-thiophenium porphyrins and their zinc-complex are reported under in vitro non-photodynamic (PDT) conditions. While all the cationic porphyrins led to the inhibition of de novo virus infection, the Zn(II)-complexes of T(OH)M (AB-type) and T(OH)M (AB-type) displayed potent inhibition of HIV-1 entry with T(OH)MZn displaying maximal anti-HIV activity. The Zinc complex of both the thiophenium porphyrins T(OH)M and T(OH)M also depicted antibacterial activities against Escherichia coli (ATCC 25922) and more prominently against Staphylococcus aureus (ATCC 25923).
View Article and Find Full Text PDFSynergistic response of physicochemical reaction parameters on biogenesis of silver nanoparticles and their action against colon cancer and leishmanial cells.
Artif Cells Nanomed Biotechnol
November 2020
Institute of Integrative Biosciences, Department of Biotechnology, CECOS University, Peshawar, Pakistan.
Physicochemical parameters include pH, temperature, the concentration of the AgNO, ratio of reactants, agitation and incubation period that act synergistically and provide a steering force to modulate the biogenesis of nanoparticles by influencing the molecular dynamics, reaction kinetics, protein conformations, and catalysis. The current study involved the bio-fabrication of silver nanoparticles (SNPs) by using the reducing abilities of (L.) L.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!