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[Effect of Staphylococcal Nuclease and Tudor Domain Containing 1/SLC7A11 on the Occurrence and Development of Osteosarcoma by Inhibiting Ferroptosis].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
February 2024
Department of Joint Surgery and Sports Medicine, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin,Guangxi 541002,China.
Article Synopsis
- This study examined how staphylococcal nuclease and tudor domain containing 1 (SND1) influences osteosarcoma cell behavior and its role in ferroptosis regulation through SLC7A11.
- Key methods included using human osteoblasts and various osteosarcoma cell lines, where SND1 expression was analyzed and knocked down to assess its effects on cell viability, proliferation, and migration.
- Findings revealed that higher SND1 levels in osteosarcoma cells correlated with increased viability, while its knockdown reduced cell growth and enhanced ferroptosis, indicating a potential target for osteosarcoma treatment.
Effects of Daidzein, Tempeh, and a Probiotic Digested in an Artificial Gastrointestinal Tract on Calcium Deposition in Human Osteoblast-like Saos-2 Cells.
Int J Mol Sci
January 2024
Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland.
Article Synopsis
- Adequate calcium intake is vital for preventing bone issues, making it important to find accessible sources of calcium, particularly for those at risk of osteoporosis.
- This study investigated the effects of tempeh, daidzein, and a specific formulation on calcium absorption and bone mineralization in a lab setup using human cell lines.
- Results showed that, while combined products could enhance cell proliferation in osteoblast-like cells, they did not significantly affect calcium accumulation, alkaline phosphatase activity, or mRNA expression related to bone health.
Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for ellipsoidal camelid red cells with decreased deformability.
J Biol Chem
February 2023
Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. Electronic address:
The red blood cells (RBCs) of vertebrates have evolved into two basic shapes, with nucleated nonmammalian RBCs having a biconvex ellipsoidal shape and anuclear mammalian RBCs having a biconcave disk shape. In contrast, camelid RBCs are flat ellipsoids with reduced membrane deformability, suggesting altered membrane skeletal organization. However, the mechanisms responsible for their elliptocytic shape and reduced deformability have not been determined.
View Article and Find Full Text PDFImpaired trafficking and instability of mutant kidney anion exchanger 1 proteins associated with autosomal recessive distal renal tubular acidosis.
BMC Med Genomics
October 2022
Siriraj Genomics, Office of the Dean, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Mutations in solute carrier family 4 member 1 (SLC4A1) encoding anion exchanger 1 (AE1) are the most common cause of autosomal recessive distal renal tubular acidosis (AR dRTA) in Southeast Asians. To explain the molecular mechanism of this disease with hematological abnormalities in an affected family, we conducted a genetic analysis of SLC4A1 and studied wild-type and mutant AE1 proteins expressed in human embryonic kidney 293T (HEK293T) cells.
Methods: SLC4A1 mutations in the patient and family members were analyzed by molecular genetic techniques.
Novel mechanism of hereditary pyropoikilocytosis phenotype due to co-inheritance of β globin and α spectrin mutations.
Am J Hematol
May 2021
Hematology, University of Utah & Huntsman Cancer Center, Salt Lake City, Utah.
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