AI Article Synopsis
- A new type of DNA-like oligomers is created using nonnatural, stable C-nucleosides with unique bases and modified structures.
- These artificial nucleosides can form right-handed duplexes and triplexes when combined with their complementary strands, showing spontaneous and selective hybridization.
- The resulting structures exhibit thermal stability comparable to natural DNA, suggesting potential applications in genetic systems for information storage and amplification.
Article Abstract
We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the beta-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.
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| http://dx.doi.org/10.1021/ja801058h | DOI Listing |
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