The pseudoexfoliative syndrome is a systemic anomaly that primarily affects the eye. Many etiopathogenic mechanisms were found using ELISA, PCR and western immunoblot. The presence of the pseudoexfoliative material causes important changes to the cornea, camerular angle, lens and zonules. Cataract surgery in pseudoexfoliative syndrome is difficult. Pseudoexfoliative glaucoma is aggressive, with great pressure differences between the two eyes, also with important circadian variations of intraocular pressure and has a reserved prognostic.
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PLoS One
January 2025
Biomedical Sciences Research Institute, Centre for Genomic Medicine, Ulster University, Coleraine, Northern Ireland, United Kingdom.
Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and translation. To investigate what glaucomatous changes occur in the trabecular meshwork and how these changes may be regulated by miRNAs, we performed a bioinformatics analysis resulting in a miRNA-mRNA interactome.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
Glaucoma Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, Iran.
Background: To compare structural and vascular parameters between advanced pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG).
Methods: One hundred and six eyes of 81 patients were enrolled in this cross-sectional study. All patients underwent complete ophthalmic examination and measurement of the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC).
Life (Basel)
January 2025
University Clinical Centre named after Prof. K. Gibiński, Medical University of Silesia, 40-514 Katowice, Poland.
Background: This study aimed to evaluate mydriasis stability during cataract surgery in patients with systemic comorbidities such as diabetes mellitus (DM) and pseudoexfoliation syndrome (PXF) after a standardised combination of intracameral mydriatics and anaesthetic (SCIMA). Stable mydriasis is crucial for safe and effective phacoemulsification.
Methods: Patients were included if they achieved pupil dilation ≥6.
Int J Mol Sci
January 2025
NDDH, Royal Devon University Healthcare NHS Foundation Trust, Barnstaple EX31 4JB, UK.
Pseudoexfoliation syndrome (PXS) is an age-related fibrillopathy where fibrillar exfoliation material accumulates and deposits in ocular and extra-ocular tissue. Within the eye, this substance accumulates on the ocular surface and in the anterior segment of the eye, impacting ocular structures such as the conjunctiva, Tenon's capsule, sclera, cornea, iris, ciliary body, trabecular meshwork, and lens. This review aims to collate the current literature on how each anatomical part of the eye is affected by PXS, with a strong focus on molecular changes.
View Article and Find Full Text PDFEur J Ophthalmol
January 2025
Ophthalmology Department, ULS São José, Lisboa, Portugal.
Purpose: To compare changes in angle morphology, anterior chamber depth (ACD) and refractive prediction error (PE) after phacoemulsification between pseudoexfoliative (PEX) and non-PEX eyes.
Methods: Prospective case-control study of eyes submitted to cataract surgery. Biometric data and angle parameters - Anterior Chamber Angle (ACA), Angle Opening Distance (AOD), Scleral Spur Angles (SSA) and Trabecular Iris Space Area (TISA) - were measured preoperatively and 1-month postoperatively through swept-source anterior segment optical coherence tomography.
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