Plenty of methods have been proposed in order to discover latent variables (features) in data sets. Such approaches include the principal component analysis (PCA), independent component analysis (ICA), factor analysis (FA), etc., to mention only a few. A recently investigated approach to decompose a data set with a given dimensionality into a lower dimensional space is the so-called nonnegative matrix factorization (NMF). Its only requirement is that both decomposition factors are nonnegative. To approximate the original data, the minimization of the NMF objective function is performed in the Euclidean space, where the difference between the original data and the factors can be minimized by employing L(2)-norm. In this paper, we propose a generalization of the NMF algorithm by translating the objective function into a Hilbert space (also called feature space) under nonnegativity constraints. With the help of kernel functions, we developed an approach that allows high-order dependencies between the basis images while keeping the nonnegativity constraints on both basis images and coefficients. Two practical applications, namely, facial expression and face recognition, show the potential of the proposed approach.
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http://dx.doi.org/10.1109/TNN.2008.2000162 | DOI Listing |
Entropy (Basel)
January 2025
Department of Physics and Fujian Provincial Key Laboratory of Low Dimensional Condensed Matter Physics, Xiamen University, Xiamen 361005, China.
We show that the theory of quantum statistical mechanics is a special model in the framework of the quantum probability theory developed by mathematicians, by extending the characteristic function in the classical probability theory to the quantum probability theory. As dynamical variables of a quantum system must respect certain commutation relations, we take the group generated by a Lie algebra constructed with these commutation relations as the bridge, so that the classical characteristic function defined in a Euclidean space is transformed to a normalized, non-negative definite function defined in this group. Indeed, on the quantum side, this group-theoretical characteristic function is equivalent to the density matrix; hence, it can be adopted to represent the state of a quantum ensemble.
View Article and Find Full Text PDFHum Mov Sci
January 2025
Department of Sports Rehabilitation, Cheongju University, Republic of Korea. Electronic address:
This study investigated muscle synergies during squats, focusing on the individual variability in motor control strategies. Sixteen healthy young adults performed 20 squats at a consistent speed. Muscle synergies were extracted using non-negative matrix factorization, followed by k-means clustering and discriminant analysis to categorize similar muscle synergies.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Neurological Care Unit, The First Affiliated Hospital of YangTze University, Jingzhou, Hubei, China.
Background: Recent years have seen persistently poor prognoses for glioma patients. Therefore, exploring the molecular subtyping of gliomas, identifying novel prognostic biomarkers, and understanding the characteristics of their immune microenvironments are crucial for improving treatment strategies and patient outcomes.
Methods: We integrated glioma datasets from multiple sources, employing Non-negative Matrix Factorization (NMF) to cluster samples and filter for differentially expressed metabolic genes.
Front Immunol
January 2025
Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Background: Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system with a high incidence that seriously threatens patients' lives and health. However, with the rise and application of new treatments, such as immunotherapy, there are still some restrictions in the treatment and diagnosis of HCC, and the therapeutic effects on patients are not ideal.
Methods: Two single-cell RNA sequencing (scRNA-seq) datasets from HCC patients, encompassing 25,189 cells, were analyzed in the study.
J Headache Pain
January 2025
Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Migraine is a complex neurological disorder characterized by recurrent episodes of severe headaches. Although genetic factors have been implicated, the precise molecular mechanisms, particularly gene expression patterns in migraine-associated brain regions, remain unclear. This study applies machine learning techniques to explore region-specific gene expression profiles and identify critical gene programs and transcription factors linked to migraine pathogenesis.
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