Purpose: To illustrate the use of superselective radiofrequency (RF) energy delivery for arterial occlusion in vessels requiring embolization.
Technique: A 3.0-F microcatheter and a 0.016-inch stainless steel microguidewire coated with polytetrafluoroethylene except for the floppy platinum-coiled tip are inserted into the diseased arteries. After positioning the microcatheter at the target site, the floppy tip of the microguidewire is advanced 1 to 2 cm beyond the microcatheter to act as an electrode. RF ablation is performed at a power of 20 watts until there was a rise in uncontrolled impedance. If occlusion is incomplete, embolic agents can be applied. The use of the technique is illustrated in 4 cases, 3 involving renal branch arteries and a large arteriovenous malformation in the buttock. RF energy was successful in occluding the target vessels in 3 cases; the other required additional embolization. There were no complications, and the patients had sustained occlusion of the lesions.
Conclusion: Diseased arteries can be endovascularly occluded using a microguidewire to deliver radiofrequency energy. However, further development of the technique is needed to circumvent wire adhesion to the arterial wall and optimize RF delivery to avoid damage to adjacent structures.
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http://dx.doi.org/10.1583/07-2321.1 | DOI Listing |
Sci Adv
January 2025
Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT 06511, USA.
Fluid shear stress (FSS) from blood flow sensed by vascular endothelial cells (ECs) determines vessel behavior, but regulatory mechanisms are only partially understood. We used cell state transition assessment and regulation (cSTAR), a powerful computational method, to elucidate EC transcriptomic states under low shear stress (LSS), physiological shear stress (PSS), high shear stress (HSS), and oscillatory shear stress (OSS) that induce vessel inward remodeling, stabilization, outward remodeling, or disease susceptibility, respectively. Combined with a publicly available database on EC transcriptomic responses to drug treatments, this approach inferred a regulatory network controlling EC states and made several notable predictions.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
College of Public Health, University of Kentucky, Lexington, KY, USA.
Background: Brain arteriolosclerosis (B-ASC) is a pathologic hallmark characterized by dysmorphic brain arteriolar wall thickening. B-ASC is a common finding at autopsy in aged persons - some degree of B-ASC is seen in >80% of brains beyond age 80 years - and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Exeter, Exeter, Devon, United Kingdom.
Background: Huntington's disease (HD) is an autosomal dominant condition causing severe neurodegeneration in the striatum and the entorhinal cortex (EC). An epigenome wide association study of DNA methylation in HD by our group, identified potential hypomethylation at the PTGDS gene in the striatum. We aimed to validate this result through pyrosequencing, examining the locus in fine detail, and to assess the signal specificity by profiling multiple neurodegenerative diseases.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Moscow, Russia.
Background: Dementia aggravates most cerebrovascular lesions, which requires differentiating the developed microcirculatory changes when making a diagnosis. We consider the features of cerebral microcirculation disorders in Alzheimer's disease (AD), distal cerebral atherosclerosis, Binswanger's disease (BD), and vascular parkinsonism (VP).
Method: The study included 1024 patients who underwent: assessment of CDR, TDR, MMSE, cerebral MRI, MRA, CT, MSCTA, scintigraphy (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA).
Alzheimers Dement
December 2024
Division of Geriatrics, Department of Internal Medicine, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil.
Background: The atherosclerotic plaque in carotid arteries has been associated with dementia. Clinic radiological studies in older adults suggest that the composition of atherosclerotic plaque in the carotid artery can predict vascular dementia (VD) or mixed dementia. The proposed study aims to assess components of atherosclerotic plaques in the carotid arteries, particularly concerning cerebrovascular lesions using racially diverse autopsy samples.
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