AI Article Synopsis
- The study aimed to use special brain scans (fMRI) to see how blood flow changes during the start and spread of an epileptic seizure.
- It involved a 20-year-old woman who experienced a seizure that made her mouth move on one side, and the researchers tracked brain activity before, during, and after the seizure.
- The results showed that certain brain areas started to become active before the woman even noticed her seizure, providing clues that might help in treating patients with epilepsy who don't respond to medicine.
Article Abstract
Aim: To visualize by ictal, functional MRI, the initial haemodynamic change (i.e. putative seizure-onset zone) and subsequent seizure spread during an epileptic seizure.
Methods: A 20-year-old woman was investigated during a simple partial seizure consisting of right-sided mouth clonus. An internal reference curve, correlated with signal change pixelwise, was applied to obtain correlation coefficient maps. The reference curve was shifted scan by scan to examine the correlation at each time point. To demonstrate seizure onset and propagation, a lag time map was produced showing the temporal sequence of activation in various brain regions.
Results: fMRI analysis showed that the lower part of the insular cortex was activated first, and its signal alteration preceded the clinical beginning of the seizure (i.e. mouth clonus) by more than one minute. Most of the activations started before clinical seizure onset. The activation corresponding to the motor area of the right face showed only a 7.5 second-long, pre-ictal phase. BOLD signal alterations were also observed in the left caudate nucleus, left thalamus, along with various areas of the left cerebral and cerebellum hemispheres.
Conclusions: The present study demonstrates a whole-brain activity simultaneously in time and space, during an epileptic seizure. Our results also support the existence of the pre-ictal state in epilepsy. Replication of our results would be of major interest for presurgical evaluation of patients with drug-resistant epilepsy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1684/epd.2008.0187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
AN ONLINE SPIKE DETECTION AND MONITORING FRAMEWORK IN IEEG RECORDED USING BRAIN INTERCHANGE DEVICE.
Proc Int Brain Comput Interface Conf
September 2024
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
In this study, we developed and validated an online analysis framework in MATLAB Simulink for recording and analysis of intracranial electroencephalography (iEEG). This framework aims to detect interictal spikes in patients with epilepsy as the data is being recorded. An online spike detection was performed over 10-minute interictal iEEG data recorded with Brain Interchange CorTec in three human subjects.
View Article and Find Full Text PDFThalamic stereo-electroencephalography exploration in pediatric drug-resistant epilepsy: implantation technique and complications.
J Neurosurg Pediatr
January 2025
2Neurology, UT Southwestern, Dallas, Texas.
Objective: Patients with drug-resistant epilepsy (DRE) are often referred for phase II evaluation with stereo-electroencephalography (SEEG) to identify a seizure onset zone for guiding definitive treatment. For patients without a focal seizure onset zone, neuromodulation targeting the thalamic nuclei-specifically the centromedian nucleus, anterior nucleus of the thalamus, and pulvinar nucleus-may be considered. Currently, thalamic nuclei selection is based mainly on the location of seizure onset, without a detailed evaluation of their network involvement.
View Article and Find Full Text PDFDetecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy.
Epilepsia
January 2025
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Objective: Somatic variants causing epilepsy are challenging to detect, as they are only present in a subset of brain cells (e.g., mosaic), resulting in low variant allele frequencies.
View Article and Find Full Text PDFResting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes.
Front Neuroimaging
December 2024
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Article Synopsis
- The study investigates the effectiveness of resting-state functional MRI (rs-fMRI) in localizing the seizure onset zone (SOZ) in epilepsy surgery through comparison with other methods like EEG and surgical outcomes.
- Over 9,500 articles were reviewed, leading to 25 that met inclusion criteria, highlighting various comparative modalities, with rs-fMRI showing significant variability in agreement when compared to different methods.
- Results showed that surgical outcomes had better agreement with rs-fMRI than EEG and intracranial EEG, and the study provided meaningful insights into the heterogeneity of SOZ identification using rs-fMRI techniques.
Beyond Seizures: Psychiatric comorbidities in children with epilepsy.
Epilepsy Behav
December 2024
Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:
Purpose: Children with epilepsy are at an increased risk of developing psychiatric comorbidities, which exacerbate the overall disease burden. However, these disorders are often underreported in developing countries. This study, conducted in a developing country, aims to evaluate the frequency of psychiatric disorders and associated factors in a large cohort of children with epilepsy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!