Objectives: We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden.
Design And Methods: We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls.
Results: In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.2 to 1.0.
Conclusions: The EPCR A1 haplotype tends to modulate the risk for RPL in carriers of factor V Leiden.
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| http://dx.doi.org/10.1016/j.clinbiochem.2008.05.004 | DOI Listing |
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