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Continuity and sustainability of care in family medicine: Assessing its association with quality of life and health outcomes in older populations-A systematic review.
PLoS One
December 2024
Associate Professor of Family Medicine, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
Background: Continuity of care is a core principle of family medicine associated with improved outcomes. However, fragmentation challenges sustaining continuous relationships. This review aimed to provide timely and critical insights into the benefits of continuity and sustainability of care for older adults.
View Article and Find Full Text PDFExtinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases.
Mol Med
December 2024
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Article Synopsis
- - The study explores the potential of chlorquinaldol (CQ), an antimicrobial agent, as a specific inhibitor of the NLRP3 inflammasome, which is linked to various inflammatory diseases, highlighting its promise for drug repurposing.
- - CQ effectively suppresses NLRP3 inflammasome activation in both mouse and human macrophages primarily by blocking the interaction between NLRP3 and ASC, while having minimal impact on other inflammasomes like NLRC4 and AIM2.
- - In vivo tests showed that CQ significantly improves conditions in mouse models of LPS-induced peritonitis, DSS-induced colitis, and MSU-induced gouty arthritis, suggesting its therapeutic potential for treating NLRP3-related
The interactivity and independence of Recovery challenges and coping strategies for ICU survivors and their caregivers: a systematic review and Meta-synthesis.
BMC Nurs
December 2024
Department of Surgical Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, #246 JingWu Road, Jinan, 250021, China.
Background: The post-ICU home recovery period requires patients and caregivers to confront recovery challenges and adopt coping strategies as a family dyad, necessitating effective dyadic interaction patterns. Existing qualitative research shows that the dyads face interactive or independent challenges and employs varying coping strategies, which may include strong communication or, conversely, avoidance. However, a single qualitative study alone might offer limited generalizability, and there is a lack of broader, more nuanced understanding about the recovery challenge and copings among ICU survivors and caregivers.
View Article and Find Full Text PDFReorienting health systems towards a PHC approach: why you cannot do it without enabling legal systems.
BMJ Glob Health
December 2024
Special Programme on Primary Health Care, World Health Organization, Geneva, Switzerland.
A Compelling Health Promoting Primary Care Clinic Using a Settings-Based Approach: A Demonstration Project.
Am J Lifestyle Med
December 2024
Department of Public Health, North Dakota State University (NDSU), Fargo, ND, USA.
The Ottawa Charter for Health Promotion, issued by the World Health Organization in 1986, called for several strategies to promote the public's health. One of the strategies was to create health-promoting health services. Over 35 years have passed since the Ottawa Charter was released, since then, efforts to improve health care have been implemented such as the Patient-Centered Medical Home, the Triple Aim, and the Affordable Care Act, yet little has been done to reorient the cultural and physical environment of health care services to one focused on health promotion.
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