AI Article Synopsis
- The study investigated neurons that express neuroendocrine secretory protein 55 (NESP55) using retrograde tracing techniques.
- NESP55 positive neurons in the rat superior cervical ganglion send projections to various targets, such as the submandibular gland and forehead skin, but not the thyroid.
- Notably, a significant portion of these neurons also contained neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP), indicating that NESP55 may play a functional role in certain sympathetic neuron populations.
Article Abstract
The peripheral projections of neurons expressing neuroendocrine secretory protein 55 (NESP55), a novel member of the chromogranin family, were studied by retrograde tracing technique. It was found that NESP55 positive neurons in the rat superior cervical ganglion projected to a number of targets including the submandibular gland, the cervical lymph nodes, the forehead skin, the iris, but not to the thyroid. Among these NESP55 positive target-projecting neurons, a subpopulation contained neuropeptide Y (NPY), a vasoconstrictor. Forepaw pad projecting neurons were found exclusively in the stellate ganglion, almost all of which (approximately 90%) were immunoreactive to NESP55. Colocalization of NESP55 and calcitonin gene-related peptide (CGRP), a peptide involved in sudomotor effects, was observed in a subpopulation of these paw pad projecting neurons, as was colocalization of NESP55 and NPY. The data suggest that NESP55 may have a functional role in some populations of sympathetic neurons.
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| http://dx.doi.org/10.1016/j.autneu.2008.03.008 | DOI Listing |
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