In this issue of Molecular Cell, Meulmeester et al. (2008) identify USP25 as a SUMO2/3-interacting protein and substrate. A USP25 SUMO interaction motif directs SUMO2/3 specificity, and SUMO modification diminishes USP25's ability to bind and degrade polyubiquitin chains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753972 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2008.05.010 | DOI Listing |
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