Integral membrane proteins perform crucial cellular functions and are the targets for the majority of pharmaceutical agents. However, the hydrophobic nature of their membrane-embedded domains makes them difficult to work with. Here, we describe a shotgun proteomic method for the high-throughput analysis of the membrane-embedded transmembrane domains of integral membrane proteins which extends the depth of coverage of the membrane proteome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765231 | PMC |
| http://dx.doi.org/10.1021/pr700795f | DOI Listing |
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