AI Article Synopsis
- The study utilized a (HR)-ICP-MS method to analyze metallic alloy components (Ti, V, Cr, Co, Ni, Mo) in the blood and urine of patients with hip and knee prostheses.
- It compared these levels to a control group of patients without metallic implants, showing that most metal concentrations were similar between the two groups.
- Elevated titanium levels were specifically noted in the urine and blood of patients with titanium alloy prostheses, highlighting the effectiveness of this multielement analysis in complex biological samples.
Article Abstract
The main components (Ti, V, Cr, Co, Ni, and Mo) of metallic alloys currently used in hip and knee articular prostheses have been simultaneously determined in human whole blood and urine of implanted people by a (HR)-ICP-MS method previously developed in our laboratory. The determination of those elements has been carried out in patients with knee and hip prosthesis and in a group of pre-operation patients without any metallic device in their bodies, used as controls, demonstrating the usefulness of this technique to perform multielement analysis at ppt levels in complex matrices. The concentrations of V, Cr, Co, Ni, and Mo in urine and blood of implanted people turned out to be very similar to those obtained in control patients. However, raised Ti levels could be found both in urine and blood of patients with articular prostheses made or coated with a titanium alloy (Ti(6)Al(4)V).
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| http://dx.doi.org/10.1007/s00216-008-2188-4 | DOI Listing |
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