AI Article Synopsis
- Eukaryotic mRNA traditionally believed to have one translation start site, encoding a single protein, but recent findings show multiple start sites exist.
- Studies indicate that eukaryotic ribosomes can recognize these alternative start sites, with many examples confirmed through experimentation.
- The importance of alternative translation events in increasing the complexity of the eukaryotic proteome has been highlighted by computational evaluations.
Article Abstract
It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative translation is growing rapidly. Also, the frequent occurrence of alternative translation events and their functional significance are supported by the results of computational evaluations. The functional role of alternative translation and its contribution to eukaryotic proteome complexity are discussed.
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| http://dx.doi.org/10.1002/bies.20771 | DOI Listing |
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