AI Article Synopsis
- The study examined the effect of weight loss from laparoscopic adjustable gastric banding (LAGB) on adipocyte fatty acid-binding protein (A-FABP) levels in severely obese women.
- After a year, participants lost an average of 24.9 kg, improving metabolic parameters, but A-FABP levels remained stable overall.
- In a closer examination of a subgroup, A-FABP levels peaked 3 months post-surgery, indicating that it might be a marker for weight loss changes rather than a stable marker for metabolic syndrome.
Article Abstract
Objective: Adipocyte fatty acid-binding protein (A-FABP) is a plasma biomarker recently associated with the metabolic syndrome. The aim of these studies was to investigate changes of A-FABP during profound weight loss induced by laparoscopic adjustable gastric banding (LAGB).
Methods And Procedures: In study one, 29 severely obese female subjects were examined before and 1 year after surgical treatment. A subgroup of 10 patients was investigated in 3-month intervals. Metabolic parameters were determined using standard methods, and A-FABP was detected using a commercially available enzyme-linked immunosorbent assay.
Results: Mean weight loss after 1 year was 24.9 kg (P < 0.001), mainly due to a decrease in fat mass. Metabolic parameters improved substantially. However, serum A-FABP remained stable. In study two, a subgroup of 10 patients was examined quarterly to determine the time course of A-FABP changes. Quarterly measurements of serum A-FABP were significantly higher than baseline levels with the highest A-FABP value after the first 3 months, where patients had highest weight loss.
Discussion: Our results in study one show that A-FABP serum levels are positively associated with body weight and fat mass. However, 1 year after pronounced weight loss A-FABP levels remained unchanged. In study two, time course analyses revealed maximum increase of serum A-FABP in parallel to highest weight loss, which allows to suppose that A-FABP is not only a biomarker of the metabolic syndrome in the steady state, but also a marker of weight changes in dynamic situations.
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| http://dx.doi.org/10.1038/oby.2008.273 | DOI Listing |
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