AI Article Synopsis
- * Advances in technology enable detailed analysis of genetic mutations, which could help identify individuals' cancer risk levels and provide opportunities for early intervention.
- * The future of colorectal cancer care may involve personalized treatment plans based on genetic information, improving prevention, diagnosis, classification, and therapeutic strategies.
Article Abstract
Colorectal cancer remains one of the most common cancers in the Western world and amongst the top three causes of cancer morbidity and death. Cancer is caused by genetic mutations, but currently there is little use of genetic information in the clinic with the exception of establishing germline mutations for the uncommon predisposing syndromes. Rapid advances in technologies allowing high throughput analysis of germline and somatic mutations raises the possibility that genetics will find a major role in the clinic distinguishing individuals at low to high risk of cancer, allowing early intervention and stratification of cancers based on mutational pathways for therapeutic interventions. In the future, this will lead to treatment regimes tailored to the individuals and their tumor. Here, we summarize the genetics underlying colorectal cancer and the future role of genetics in prevention, diagnosis, classification and treatment.
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| http://dx.doi.org/10.1016/j.prp.2008.03.003 | DOI Listing |
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