Antibiotic-loaded bone cement is extensively used in joint arthroplasty, but increasing bacteria resistance against common antibiotics has lead to a demand for alternative drugs. However, bone cement containing new additives must be characterized both biologically and mechanically. This study evaluated elution kinetics, antibacterial activity, and mechanical properties for cement loaded with vancomycin and/or meropenem. The presence of meropenem broadened the antibacterial spectrum and enhanced the elution of vancomycin. The mechanical properties were negatively affected by 1.0 g of vancomycin, but these detrimental effects were acceptable when only 0.5 g of vancomycin were added to a cement containing 0.5 g of meropenem. Further investigations on this formulation with adjusted antibiotic amounts are, however, necessary to reach the optimal compromise between the antibacterial and the mechanical properties of the bone cement.
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http://dx.doi.org/10.1016/j.arth.2007.10.010 | DOI Listing |
Indian J Orthop
February 2025
Orthopaedics, Fortis, Mohali, India.
Introduction: To study the incidence of bone cement implantation syndrome in elderly patients undergoing cemented stem hip arthroplasty with the use of pulse lavage.
Materials And Methods: 40 consecutive patients undergoing cemented stem hip arthroplasty enrolled in the study and intra-operative vitals post induction and post cementing were recorded at 5, 10 and 15 min.
Results: Study depicted an incidence of 32.
Exp Ther Med
March 2025
OrthoLab, The Rudbeck Laboratory, Department of Surgical Sciences/Orthopedics, Uppsala University, 75185 Uppsala, Sweden.
Silver (Ag) possesses potent antimicrobial properties and is used as a coating for medical devices. The impact of silver ions released from orthopedic implants on the differentiation and osteoid formation of different osteogenic cells has yet to be systematically studied. In the present study, human mesenchymal stem cells (hMSCs) and primary human osteoblasts (hOBs) were exposed to different static Ag concentrations (0, 0.
View Article and Find Full Text PDFNo Shinkei Geka
January 2025
Department of Neurosurgery, Takeda General Hospital.
Vertebroplasty has shown excellent analgesic effects in patients with osteoporotic vertebral fractures. In Japan, percutaneous vertebroplasty, balloon kyphoplasty, and vertebral body stenting are commonly performed. All of these techniques require precise transpedicular vertebral puncture and complete cement filling without leakage.
View Article and Find Full Text PDFJ Arthroplasty
January 2025
Department of Orthopaedic Surgery, University of Virginia, 2280 Ivy Road, Charlottesville, VA, 22903, United States of America.
Introduction: Debate surrounding the use of cemented femoral components in hip arthroplasty persists. A proposed risk of cement fixation is bone cement implantation syndrome (BCIS), a phenomenon characterized by intraoperative hypotension, hypoxia, and/or cardiovascular collapse. The purpose of this study was to analyze the literature to determine if enough evidence exists to support a causal relationship between cement and BCIS.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Korea.
Polylactic acid (PLA) has garnered attention for use in interim dental restorations due to its biocompatibility, biodegradability, low cost, ease of fabrication, and moderate strength. However, its performance under intraoral conditions, particularly under heat and moisture, remains underexplored. This study evaluated the mechanical properties of PLA interim crowns compared with those of polymethylmethacrylate (PMMA) and bisphenol crowns under simulated intraoral conditions with thermocycling.
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