Central pontine myelinolysis and extrapontine myelinolysis are rare complications of rapid correction of chronic hyponatremia. Central pontine myelinolysis is more common and more predictable in presentation. Extrapontine myelinolysis' presenting symptoms vary and may be as general as lethargy or altered mood. We report experience with a patient who developed only extrapontine myelinolysis after rapid correction of severe hyponatremia associated with gastroenteritis. His presenting sign, generalized seizures, has not been previously reported. We summarize risk factors for myelinolysis, which may be more common than previously thought, as well as steps to minimize risk while managing vulnerable patients.
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http://dx.doi.org/10.1016/j.ajem.2007.10.007 | DOI Listing |
Medicine (Baltimore)
December 2024
Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Rationale: Osmotic demyelination syndrome (ODS) is a noninflammatory demyelinating disorder involving the pontis and other regions of the central nervous system. This article tries to enhance the understanding of ODS. Combined with clinical features, we use laboratory/imaging examination and literature review.
View Article and Find Full Text PDFJ Neurol Sci
December 2024
Department of Neurology, Affiliated Hospital of Hebei Engineering University, No.81 Congtai Road, Congtai District, Handan 056002, Hebei Province, China. Electronic address:
Objective: To describe the clinical characteristics, therapeutic approaches, and prognostic outcomes of osmotic demyelination syndrome (ODS) in cancer patients.
Methods: A comprehensive literature search (January 1950-March 2024) using PubMed, Embase, Cochrane Library, and Web of Science. Keywords included "osmotic demyelination and cancer", "central pontine myelinolysis and cancer", and "extrapontine myelinolysis and cancer", "Osmotic demyelination and malignancy," "Central pontine myelinolysis and malignancy," and "Extrapontine myelinolysis and malignancy.
Cureus
October 2024
Internal Medicine, Dubai Health, Dubai, ARE.
Central pontine myelinolysis (CPM) is a demyelinating disorder often associated with the rapid correction of hyponatremia. Elevated creatine phosphokinase (CPK) levels have been observed in some cases of CPM but are not well studied. A 38-year-old patient with chronic alcohol use disorder presented with jerky movements, confusion, and disorientation following severe hyponatremia.
View Article and Find Full Text PDFJ Eat Disord
November 2024
Peking University Sixth Hospital, No.51 Hua Yuan North Road, Hai Dian District, Beijing, 100191, China.
Neurohospitalist
September 2024
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
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