Unlabelled: Although congenital partial hypodontia is widespread, and a variety of solutions for treating this condition in adolescents have been devised, all have had one or more significant drawbacks. A new treatment option that has recently become available, the Procera Maryland Bridge, appears to deliver excellent esthetics and strength. This article discusses that option and presents a case in which it was used successfully.
Clinical Significance: Congenitally missing lateral incisors always present a treatment dilemma for restorative dentists. Numerous treatment options exist; none of which are totally satisfactory. This article presents a potential alternative for these patients using a novel all-ceramic Maryland Bridge.
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http://dx.doi.org/10.1111/j.1708-8240.2008.00172.x | DOI Listing |
Environ Sci Technol
January 2025
Key Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, Peoples R China.
Increasing antimicrobial resistance (AMR) poses a substantial threat to global health and economies, which has led many countries and regions to develop AMR National Action Plans (NAPs). However, inadequate logistical capacity, funding, and essential information can hinder NAP policymaking, especially in low-to-middle-income countries (LMICs). Therefore, major gaps exist between aspirations and actions, such as fully operationalized environmental AMR surveillance programs in NAPs.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Syreon Research Institute, Budapest, Hungary.
Background: Non-adherence to medication remains a persistent and significant challenge, with profound implications for patient outcomes and the long-term sustainability of healthcare systems. Two decades ago, the World Health Organization (WHO) dedicated its seminal report to adherence to long-term therapies, catalysing notable changes that advanced both research and practice in medication adherence. The aim of this paper was to identify the most important progress made over the last 2 decades in medication adherence management and to initiate a discussion on future objectives, suggesting priority targets for the next 20 years.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Physician Assistant Leadership and Learning Academy, University of Maryland, 520 West Fayette St, Suite 130, 21201, Baltimore, Maryland, USA.
This review paper explores the transformative impact of Artificial Intelligence (AI) on Continued Process Verification (CPV) in the biopharmaceutical industry. Originating from the CPV of the Future project, the study investigates the challenges and opportunities associated with integrating AI into CPV, focusing on real-time data analysis and proactive process adjustments. The paper highlights the importance of aligning AI solutions with regulatory standards and offers a set of comprehensive recommendations to bridge the gap between AI's potential and its practical, compliant, and safe application in pharmaceutical manufacturing.
View Article and Find Full Text PDFbioRxiv
December 2024
Department of Laboratory Medicine and Pathology, University of Washington; Seattle, WA 98195, USA.
Herpes simplex virus (HSV) infection has worldwide public health concerns and lifelong medical impacts. The standard therapy, acyclovir, has limited efficacy in preventing HSV subclinical virus shedding, and drug resistance occurs in immunocompromised patients, highlighting the need for novel therapeutics. HSV infection manifests in the skin epidermal layer, but current drug discovery utilizes Vero cells and fibroblasts monolayer cultures, capturing neither relevance nor tissue environment.
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