Free skin autotransplantation may be adequately simulated in albino chinchilla rabbits. Gradual elevation of tc PO2 in the transplanted graft is considered as a functional indicator of the time course of autodermotransplant taking in. Morphologic study has shown dystrophic changes in the graft surface layers in the early periods of healing during scab formation, because of inadequate nutrition of the flap. Later the proliferative processes activate, the vessels on the side of the graft bed grow in, the scab is rejected, and the graft surface epithelializes. The time course of circulation and structure of the graft recovery is in line with the oxygen regimen time course.
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JACC Asia
January 2025
Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time in target range (TTR) for BP since childhood on the risk of arterial stiffness in midlife remains unclear.
Objectives: The purpose of this study was to determine the independent association of TTR for systolic blood pressure (SBP) from childhood to midlife with arterial stiffness in adulthood.
Res Soc Stratif Mobil
December 2024
The University of South Carolina, Department of Sociology, Sloan College, 911 Pickens Street, Columbia, S.C. 29208.
Economic homogamy has important implications for gender inequality and for economic inequalities between households. However, the long-term association between spouses' earnings is not well understood. This study reconceptualizes economic homogamy as a life course process rather than a static state of being that can be adequately captured at a single point in time.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Certara Inc., Melbourne, VIC, Australia.
Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression analyses with binary endpoints, several exposure metrics are investigated, based on pharmacological plausibility, including time-averaged concentration to event (C). C is informative because it accounts for dose interruptions, modifications, and reductions and is therefore often compared against ER relationships identified using steady-state exposures.
View Article and Find Full Text PDFPhys Imaging Radiat Oncol
January 2025
Department of Clinical Research, University of Southern Denmark, Denmark.
Background And Purpose: Daily magnetic resonance image (MRI)-guided radiotherapy plan adaptation requires time-consuming manual contour edits of targets and organs at risk in the online workflow. Recent advances in auto-segmentation promise to deliver high-quality delineations within a short time frame. However, the actual time benefit in a clinical setting is unknown.
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