A 18 year-old soldier, heroin-addict, presented with the association of myasthenia gravis and HIV infection with a specific subacute encephalopathy. To our knowledge, it is the second reported case. This association may result from an immune dysregulation due to nonspecific thymic modifications, which has been reported in AIDS.
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Front Biosci (Landmark Ed)
January 2025
Department of Surgery, Laboratory of Tumor Immunology and Immunotherapy, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Immunology advances have increased our understanding of autoimmune, auto-inflammatory, immunodeficiency, infectious, and other immune-mediated inflammatory diseases (IMIDs). Furthermore, evidence is growing for the immune involvement in aging, metabolic and neurodegenerative diseases, and different cancers. However, further research has indicated sex/gender-based immune differences, which further increase higher incidences of various autoimmune diseases (AIDs), such as systemic lupus erythematosus (SLE), myasthenia gravis, and rheumatoid arthritis (RA) in females.
View Article and Find Full Text PDFAutoimmun Rev
October 2024
Zabludowicz center for autoimmune diseases, Sheba Medical Center, Ramat Gan. Israel; Reichman University, Herzelia, Israel.
Autoimmune diseases (AIDs) affect 5 to 10% of the population. There are more than ∼100 different autoimmune diseases. The AIDs are one of the top 10 causes of death in women under 65; 2nd highest cause of chronic illness; top cause of morbidity in women in the US.
View Article and Find Full Text PDFWorld Neurosurg
November 2024
Department of Orthopedics, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming City, Yunnan Province, China; The Key Laboratory of Digital Orthopedics of Yunnan Province, Kunming City, Yunnan Province, China. Electronic address:
This review aims to comprehensively summarize the application of electrophysiological methods, specifically repetitive nerve stimulation (RNS) and single fiber electromyography (SFEMG), in the diagnosis of neuromuscular junction (NMJ) disorders, including myasthenia gravis, Lambert-Eaton syndrome, and sarcopenia in the elderly. Both RNS and SFEMG have demonstrated high sensitivity and specificity in detecting NMJ abnormalities. RNS aids in distinguishing presynaptic from postsynaptic lesions, while SFEMG provides direct evidence of NMJ function by assessing single motor unit action potentials.
View Article and Find Full Text PDFCureus
May 2024
Family Medicine, Edward Via College of Osteopathic Medicine, Monroe, USA.
Myasthenia gravis (MG) is a rare disorder that most commonly presents with ocular symptoms. Despite the highly sensitive blood work that can be used to diagnose the disease, it is frequently misdiagnosed until the disease becomes systemic. Literature, however, shows that those who begin treatment with acetylcholinesterase inhibitors before systemic presentation have a better prognosis.
View Article and Find Full Text PDFReprod Sci
January 2025
Department of Obstetrics and Gynecology, Gansu Provincial Clinical Research Center for Gynecological Oncology, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China.
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