Comparative fate of the tritiated trichothecene mycotoxin, T-2 toxin, in chickens and ducks.

Poult Sci

USDA, Food Animal Protection Research Laboratory, College Station, Texas 77845.

Published: May 1991

A tritiated preparation of the trichothecene mycotoxin, T-2 toxin, was administered as a single oral dose to 21-day-old male broiler (Hubbard x Hubbard) chickens and White Pekin ducks. There were few significant differences between the two species in metabolism, tissue retention, and excretion of T-2 toxin and its metabolites. On the basis of the data obtained, the differences in toxicological sensitivity to T-2 toxin known to exist between these two species cannot likely be attributed to differences in the metabolism or elimination of T-2 toxin from the body.

Download full-text PDF

Source
http://dx.doi.org/10.3382/ps.0701138DOI Listing

Publication Analysis

Top Keywords

t-2 toxin
20
trichothecene mycotoxin
8
mycotoxin t-2
8
t-2
5
toxin
5
comparative fate
4
fate tritiated
4
tritiated trichothecene
4
toxin chickens
4
chickens ducks
4

Similar Publications

T-2 toxin triggers immunotoxic effects in goats by inducing ferroptosis and neutrophil extracellular traps.

Toxicol Appl Pharmacol

January 2025

College of Veterinary Medicine, Southwest University, Chongqing 400715, China. Electronic address:

T-2 toxin, a prevalent mycotoxin, represents a notable global public health risk. Neutrophil extracellular traps (NETs) and ferroptosis are involved in a variety of pathophysiological processes and are implicated in goat immunity. However, the impact of T-2 toxin on NETs release, ferroptosis, and their interplay have not been previously documented.

View Article and Find Full Text PDF

Ultrabright aggregation-induced materials for the highly sensitive detection of Ag and T-2 toxin.

Food Chem

January 2025

State Key Laboratory for Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China; Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. Electronic address:

Heavy metals and mycotoxins are important contaminants in food pollution. Sensitive, reliable, and rapid detection of heavy metals and mycotoxins is crucial for human health. In this work, imidazole-functionalized aggregation-induced emission (AIE) molecule tetra-(4-pyridylphenyl) ethylene (TPPE) was used as a precise and specific probe for Ag detection, with a limit of detection (LOD) of 0.

View Article and Find Full Text PDF

Downregulation of HSP47 triggers ER stress-mediated apoptosis of hypertrophic chondrocytes contributing to T-2 toxin-induced cartilage damage.

Environ Pollut

January 2025

School of Public Health, Health Science Center, Xi'an Jiaotong University, NHC Key Laboratory of Environment and Endemic Diseases, No. 76 Yanta West Road, Xi'an, 710061, Shaanxi, PR China. Electronic address:

T-2 toxin contamination in food and feed is a growing global concern, with its toxic effects on developing cartilage remaining poorly understood. In this study, we constructed an animal model using 4-week-old male Sprague-Dawley rats, which were administered T-2 toxin (200 ng/g body weight per day) by gavage for one month. Histological analysis showed a significant reduction in hypertrophic chondrocytes and increased caspase-3 expression and TUNEL staining in the deep cartilage zone of T-2 toxin-treated rats.

View Article and Find Full Text PDF

Co-occurrence of multiple mycotoxins is a growing global food safety concern due to their harmful effects on humans and animals. This study developed an eco-friendly sample preparation method and an innovative multiplex microarray-based lateral flow immunoassay, using a novel portable reader for on-site simultaneous determination of five regulated mycotoxins-aflatoxin B, T-2 toxin, zearalenone, deoxynivalenol, and fumonisin B in rice. The eco-friendly and ultrafast extraction procedure utilizes a bio-based solvent.

View Article and Find Full Text PDF

Mycotoxins are secondary metabolites of fungi and represent a serious problem for human health. Due to growing interest, various aspects have been widely studied by scientific groups. One of these aspects relates to the food industry and associated beer production.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!