AI Article Synopsis
- Stress exposure can trigger psychiatric disorders in vulnerable people, but the exact biological mechanisms are not fully known.
- Using forced swimming tests on different mouse strains, researchers identified distinct stress-regulated genes in the hippocampus, highlighting individual variations in stress response.
- The study emphasizes a phased reaction to stress at the gene level and points to new pathways connected to neuronal plasticity, focusing on the gene dihydropyrimidinase like 2 and its regulation by NeuroD, which plays a crucial role in neuron development.
Article Abstract
Stress exposure can lead to the precipitation of psychiatric disorders in susceptible individuals, but the molecular underpinnings are incompletely understood. We used forced swimming in mice to reveal stress-regulated genes in the CA3 area of the hippocampus. To determine changes in the transcriptional profile 4 h and 8 h after stress exposure microarrays were used in the two mouse strains C57BL/6J and DBA/2J, which are known for their differential stress response. We discovered a surprisingly distinct set of regulated genes for each strain and followed selected ones by in situ hybridisation. Our results support the concept of a phased transcriptional reaction to stress. Moreover, we suggest novel stress-elicited pathways, which comprise a number of genes involved in the regulation of neuronal plasticity. Furthermore, we focused in particular on dihydropyrimidinase like 2, to which we provide evidence for its regulation by NeuroD, an important factor for neuronal activity-dependent dendritic morphogenesis.
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| http://dx.doi.org/10.1016/j.mcn.2008.04.005 | DOI Listing |
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