AI Article Synopsis
- The study aimed to assess two methods—liver-to-muscle signal intensity and R2*—for measuring liver iron levels with potential clinical applications.
- Research involved 16 liver phantoms and 33 human subjects using three different MRI scanners, which showed strong correlations between the MRI results and actual iron concentrations in both phantoms and human subjects.
- Both methods proved reliable for indicating iron levels, with R2* showing consistency across different scanners, although further testing is necessary to confirm their transferability to various devices.
Article Abstract
Purpose: To evaluate the liver-to-muscle signal intensity and R2* methods to gain a transferable, clinical application for liver iron measurement.
Materials And Methods: Sixteen liver phantoms and 33 human subjects were examined using three 1.5-T MRI scanners from two different vendors. Phantom-to-muscle and liver-to-muscle signal intensity ratios were analyzed to determine MRI estimated phantom and hepatic iron concentration (M-PIC and M-HIC, respectively). R2* was calculated for the phantoms and the liver of human subjects. Seven patients' biochemical hepatic iron concentration was obtained.
Results: M-PIC and R2* results of three scanners correlated linearly to phantom iron concentrations (r=0.984 to 0.989 and r=0.972 to 0.981, respectively), and no significant difference between the scanners was found (P=.482 and P=.846, respectively) in vitro. The patients' R2* correlated linearly to M-HIC of the standard scanner (r=0.981). M-HIC values did not differ from those obtained from the biopsy specimens (P=.230). The difference in M-HIC was significant, but the difference in R2* was not significant between the scanners (P<.0001 and P=.505, respectively) in vivo.
Conclusion: Both methods, M-HIC and R2*, are reliable iron concentration indicators with linear dependence on iron concentration in vivo and in vitro. The R2* method was found to be comparable among different scanners. Transferability testing is needed for the use of the methods at various scanners.
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| http://dx.doi.org/10.1016/j.mri.2008.01.028 | DOI Listing |
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