Complete and unambiguous assignments of 1H and 13C chemical shifts of new arylamino derivatives of ortho-naphthofuranquinones.

Magn Reson Chem

Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho, 24020-141, Niterói, RJ, Brazil.

Published: December 2008

Six new nor-beta-lapachones have been synthesized from reaction of 3-bromo-nor-beta-lapachone with arylamines. These derivatives have potent anticancer properties against several cell lines. Here, we report complete unambiguous assignments of (1)H and (13)C chemical shifts of the new compounds. The assignments were made using a combination of one- and two-dimensional NMR techniques ((1)H, (13)C, (1)H-(1)H COSY, (1)H-(13)C HSQC, and (1)H-(13)C HMBC).

Download full-text PDF

Source
http://dx.doi.org/10.1002/mrc.2250DOI Listing

Publication Analysis

Top Keywords

complete unambiguous
8
unambiguous assignments
8
assignments 13c
8
13c chemical
8
chemical shifts
8
shifts arylamino
4
arylamino derivatives
4
derivatives ortho-naphthofuranquinones
4
ortho-naphthofuranquinones nor-beta-lapachones
4
nor-beta-lapachones synthesized
4

Similar Publications

Differences/disorders of sex development (DSDs) are a diverse group of congenital conditions that result in disagreement between an individual's sex chromosomes, gonads, and/or anatomical sex. The 46, XY DSD group is vast and includes various conditions caused by genetic variants, hormonal imbalances, or abnormal sensitivity to testicular hormones, leading to varying degrees of under-virilization. A 19-year-old phenotypically normal female from Kakamega, Kenya, presented with primary amenorrhea.

View Article and Find Full Text PDF

Peach-associated luteovirus (PaLV) belongs to the genus Luteovirus, family Tombusviridae. To date, PaLV has only been reported in peach (Prunus persica) and its presence detected in the Republic of Georgia (Wu et al., 2017), China (Zhou et al.

View Article and Find Full Text PDF

We developed a technique allowing the direct observation of photoinduced charge-transfer states (CTSs)-the weakly coupled electron-hole pairs preceding the completely separated charges in organic photovoltaic (OPV) blends. Quadrature detection of the electron spin echo (ESE) signal enables the observation of an out-of-phase ESE signal of CTS. The out-of-phase Electron-Electron Double Resonance (ELDOR) allows measuring electron-hole distance distributions within CTS and its temporal evolution in the microsecond range.

View Article and Find Full Text PDF

-(tetra-aryl) picket calix[4]pyrrole 1 featuring -fluorophenyl groups at all four -positions in a -configuration has been synthesized and characterized unambiguously using single-crystal X-ray diffraction analysis. This pre-organized system possesses a deep binding pocket created by the four aryl groups so that anions can be accommodated through anion-π interactions and four-point N-H⋯anion hydrogen bonds. Single-crystal X-ray diffraction analysis of the CsF and TEAF (TEA = tetraethylammonium) complexes of receptor 1 unequivocally confirms the formation of 1 : 1 complexes, revealing the binding modes in the solid state.

View Article and Find Full Text PDF

Searching for a serial killer on a hospital ward.

Forensic Sci Int

December 2024

Tampere University, Faculty of Social Sciences, Arvo building, Arvo Ylpon katu 34, Tampere, Finland.

Article Synopsis
  • The case of Lucy Letby illustrates the difficulty of identifying serial killers in healthcare settings, emphasizing the need for improved statistical methods in legal investigations.
  • A nurse was convicted for injecting an infant with insulin, and an analysis of 29 suspicious deaths in a geriatric unit revealed a significant correlation between her night shifts and the incidents.
  • While statistical methods can enhance investigative targeting, they must complement thorough investigations to accurately determine the causes of death in suspicious cases.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!