Serum micronutrient and micromineral concentrations and ratios in healthy Omani subjects.

Med Princ Pract

Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khoudh, Oman.

Published: September 2008

AI Article Synopsis

  • The study aimed to determine normal levels of key micronutrients like copper and zinc in healthy Omani men and women.
  • The research used various advanced testing methods to analyze the serum concentrations of these micronutrients and their ratios.
  • Findings revealed significant differences between genders in certain micronutrient levels, with women showing higher copper and caeruloplasmin and lower retinol and alpha-tocopherol compared to men, alongside an overall low deficiency rate across all parameters.

Article Abstract

Objective: This study aimed to establish reference ranges of serum concentrations of copper, zinc, retinol, alpha-tocopherol, copper:caeruloplasmin and copper:zinc ratios in a group of healthy Omani men and women.

Materials And Methods: Assay techniques employed were atomic absorption spectrophotometry (copper and zinc), reverse-phase high-pressure liquid chromatography with isocratic elution (retinol and alpha-tocopherol), immunonephelometry (caeruloplasmin) and spectrophotometry (albumin and cholesterol).

Results: The mean +/- SD (microM) obtained for copper, zinc, retinol, and alpha-tocopherol were 15.9 +/- 3.0, 14.2 +/- 2.0, 1.45 +/- 0.39 and 16.9 +/- 4.4, respectively. The mean +/- SD for copper:zinc and copper:caeruloplasmin ratios were 1.15 +/- 0.30 micromol/mmol and 6.99 +/- 0.84 micromol/g, respectively. Significantly higher (p < 0.0001) copper and caeruloplasmin concentrations, copper:zinc and copper:caeruloplasmin ratios and lower zinc, retinol, alpha-tocopherol, cholesterol concentrations and alpha-tocopherol:cholesterol ratio were present in women compared to men. Age appeared to be associated with copper and retinol concentrations, and copper:caeruloplasmin ratios in women; in men, the association was mostly moderate with caeruloplasmin, alpha-tocopherol, cholesterol concentrations and alpha-tocopherol:cholesterol ratios. Smokers had decreased albumin (p = 0.002), zinc (p = 0.023) concentrations, and copper:caeruloplasmin ratios (p = 0.002), increased alpha-tocopherol concentrations (p = 0.016) and alpha-tocopherol:cholesterol ratios (p = 0.021) compared with non-smokers. Deficiency incidence was < or =5% for all investigated parameters.

Conclusions: Reference ranges of micronutrient concentrations and micromineral ratios were established for Omani subjects. The mean values of several micronutrients were lower than those reported for other populations and some showed gender effects.

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http://dx.doi.org/10.1159/000129616DOI Listing

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