Glucagon release by pancreatic alpha cells is stimulated by low glucose through unclear mechanisms. In this issue of Cell Metabolism, Cabrera et al. (2008) show that glutamate released from alpha cells acts on glutamate receptors in a positive autocrine fashion that drives glucagon secretion during small physiological fluctuations of blood glucose.
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| http://dx.doi.org/10.1016/j.cmet.2008.05.003 | DOI Listing |
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