Spontaneous hematoma of the umbilical cord represents a rare cause of fetal morbidity and mortality and the outcome is poor in half of the cases. There are many risk factors, such as infections, morphologic anomalies, alterations of the vessel walls, prolapses, twisting and traction of the cord, but in many cases the causes remain unknown. We present 3 cases of umbilical cord hematoma which took place at the end of the pregnancy and were followed by perinatal death of the fetus. In the 3 cases, which were autopsied including macroscopical and histopathologic examination of the placenta and the umbilical cord, a cordonal pathology was present; in all cases, there were alterations of the vascular wall, and in the third case inflammatory vasculopathy was found. In all 3 cases, the cause of death was attributed to acute anoxia due to the cordonal hematoma.
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http://dx.doi.org/10.1097/PAF.0b013e318174e7e1 | DOI Listing |
J Perinat Med
January 2025
Department of Obstetrics & Gynaecology, 2541 Monash University, Melbourne, VIC, Australia.
Introduction: Vasa previa (VP) is a serious pregnancy complication in which fetal vessels, unprotected by the umbilical cord, run across or within close proximity to the internal cervical os, which can potentially result in fetal exsanguination in the event of membrane rupture. There is global consensus that women with antenatally diagnosed VP should have caesarean delivery prior to onset of labour to prevent the catastrophic complications of VP. However, there is variability in the approach to management of these women antenatally, particularly regarding hospitalisation and timing of steroid administration and delivery.
View Article and Find Full Text PDFCureus
December 2024
Obstetrics, Orlando Regional Medical Center, Orlando, USA.
Amniotic fluid embolism (AFE) is a rare condition that can have catastrophic maternal and infant consequences. It can lead to rapid multisystem failure and is responsible for a significant portion of maternal deaths. The diagnosis is frequently made late in the pathological process, and the treatment is mainly supportive and infant delivery.
View Article and Find Full Text PDFHeliyon
January 2025
Arsi University, Department of Midwifery, Asella, Ethiopia.
Background: Cord care is the series of steps applied to handle the umbilical cord after delivery of the newborn. Despite increasing the number of primary health facilities, unhygienic cord care remains persist.
Objective: To assess umbilical cord care practices and associated factors among mothers who gave birth in the last six months in Hetosa district, Arsi zone, Ethiopia, 2021.
Front Endocrinol (Lausanne)
December 2024
Institute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, Brazil.
Introduction: Excess weight during pregnancy is a condition that can affect both mother and fetus, through the maternal-fetal interface, which is constituted by the placenta and umbilical cord. The umbilical vein is responsible for transporting oxygen and nutrients to the fetus, and its proper functioning depends on the integrity of its structure. The remodeling of the umbilical vein represents one of the causes of inadequate transport of nutrients to the fetus, being potentially harmful.
View Article and Find Full Text PDFAnal Chem
January 2025
Interdisciplinary, Molecular Biology of Biological Function, Changbai Mountain Key Laboratory of Natural Medicine of Ministry of Education, Yanbian University, Yanji 133000, China.
Extracellular vesicles (EVs) play a crucial role in diagnosis and treatment, yet obtaining highly purified EVs from complex biological samples is often hindered by nanoscale contaminants. In this work, considering the charge-to-size characteristics of EVs, a circular multicavity electrophoresis (CME) with gradient pore size distribution was constructed in the gradient electric field to realize the isolation and preparation of EVs. By the gradient gel sieving effect, small cell debris, EVs, and proteins in biological samples were gradually separated.
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