Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493107 | PMC |
| http://dx.doi.org/10.1128/AAC.00175-08 | DOI Listing |
Publication Analysis
Top Keywords
pseudomonas aeruginosa
8
isolates bulgaria
8
bulgaria germany
8
vim-15 vim-16
4
vim-16 vim-2-like
4
vim-2-like metallo-beta-lactamases
4
metallo-beta-lactamases pseudomonas
4
aeruginosa isolates
4
germany pseudomonas
4
aeruginosa urine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!