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Gut-associated lymphoid tissue carcinoma analyzed using next-generation sequencing: A case report.
Pathol Res Pract
November 2024
Department of Pathology, Iwate Medical University School of Medicine, Morioka, Iwate 028-03694, Japan; Department of Pathology, Southern Tohoku Hospital, Koriyama, Fukushima 963-8052, Japan.
Article Synopsis
- GALT carcinomas (GCs) are tumors derived from gut-associated lymphoid tissue, typically appearing as dome-shaped lesions with distinct microscopic features like dilated glands and lymphocyte-rich stroma.
- A case study highlighted a 54-year-old man with a protruding rectal lesion, diagnosed as a GC after surgery, showing atypical tumor characteristics including a lack of common mucin markers.
- Genetic analysis revealed mutations in the EGFR and TP53 genes, differing from standard adenoma-carcinoma mutations, suggesting further investigation is needed to understand the nature and origin of GCs.
Gut-associated Lymphoid Tissue/Dome-Type Carcinoma of the Colon: A Rare Case Report With Review of the Literature.
Int J Surg Pathol
September 2023
Department of Pathology, Guiqian International General Hospital, Guiyang, Guizhou Province, China.
Gut-associated lymphoid tissue (GALT) carcinoma, also termed dome-type carcinoma, is an infrequent distinctive subtype of colorectal adenocarcinoma and only 18 cases have been reported in the English medical literature. These tumors have unique clinicopathological features and are considered to have a low malignant potential with favorable prognosis. Herein, we described a case of a 49-year-old male with intermittent hematochezia for 2 years.
View Article and Find Full Text PDFDome-type carcinoma of the rectum mimicking a submucosal tumor: a case report and literature review.
J Minim Invasive Surg
March 2022
Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.
Dome-type carcinoma (DC) has been recognized as a rare variant of adenocarcinoma, which arises in gut-associated lymphoid tissue. It has a specific morphologic feature of a dome-like protrusion associated with lymphoid tissue. We report a case of a DC of the rectum in an asymptomatic 58-year-old male.
View Article and Find Full Text PDFGut-associated lymphoid tissue or so-called "dome" carcinoma of the colon: Review.
World J Gastrointest Oncol
January 2019
Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto ON, Canada.
Aim: To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.
Methods: The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or "dome" carcinoma of the colon was searched and appraised.
Results: GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine.
DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.
Diagn Pathol
July 2015
Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland.
Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia.
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