Thermally activated barrier crossing in the presence of an increasing load can reveal kinetic rate constants and energy barrier parameters when repeated over a range of loading rates. Here we derive a model of the mean escape force for all relevant loading rates-the complete force spectrum. Two well-known approximations emerge as limiting cases, one of which confirms predictions that single-barrier spectra should converge to a phenomenological description in the slow loading limit.
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http://dx.doi.org/10.1103/PhysRevLett.100.138302 | DOI Listing |
Int Urogynecol J
January 2025
University of the Witwatersrand, Johannesburg, South Africa.
Introduction And Hypothesis: Evidence on health system challenges mostly relate to high-income countries. Lack of context-specific knowledge, educational opportunities, and access to resources among pelvic health care providers could be barriers to effective implementation of pelvic health services in South Africa. The aim of this study was to determine the patient and therapist profile, and the educational and resource needs of pelvic health physiotherapists in South Africa.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
January 2025
Department of Pathology, Jinnah Sindh Medical University, Karachi, Pakistan.
Objective: To determine the clinical microbial synergy in skin and soft tissue infections (SSTIs) based on bacterial groups and explore the likelihood ratios of clinical parameters.
Study Design: Descriptive cross-sectional study. Place and Duration of the Study: The study was conducted at the Department of Microbiology, University of Karachi in collaboration with Jinnah Postgraduate Medical Centre, and Jinnah Sindh Medical University, Karachi, Pakistan, from June 2023 to May 2024.
BMC Public Health
January 2025
Department of Nursing, School of Medicine, Lishui University, No. 1 Xueyuan Road, Lishui City, Zhejiang Province, 323000, China.
Background: Identifying the level of healthy aging and exploring its associated factors are prerequisites in the planning of effective measures among the elderly population. Thus, this study aimed to investigate the prevalence of healthy aging and determine its associated factors among community-dwelling older adults from mountain areas in Lishui, China.
Methods: A multicenter cross-sectional survey was conducted.
J Gen Intern Med
January 2025
VA Portland Health Care System, Center to Improve Veteran Involvement in Care, 3710 SW U.S. Veterans Hospital Road, Portland, OR, 97239, USA.
Background: Gulf War illness (GWI) is characterized by multiple, persistent symptoms (e.g., fatigue, musculoskeletal pain, concentration problems, and gastrointestinal disorders) across more than one body system that are severe enough to interfere with daily functioning.
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India. Electronic address:
Temozolomide is universally used to treat glioblastoma due to its unique ability to cross the blood-brain barrier and inhibit tumor growth through DNA alkylation. However, over time, the inevitable emergence of resistance to temozolomide impedes successful treatment of this cancer. As a result, there is an urgent need to identify new therapeutic targets to improve treatment outcomes for this malignancy.
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