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Imaging biomarkers of cortical neurodegeneration underlying cognitive impairment in Parkinson's disease.
Eur J Nucl Med Mol Imaging
January 2025
Reina Sofia Alzheimer Center, CIEN Foundation, ISCIII, Madrid, Spain.
Purpose: Imaging biomarkers bear great promise for improving the diagnosis and prognosis of cognitive impairment in Parkinson's disease (PD). We compared the ability of three commonly used neuroimaging modalities to detect cortical changes in PD patients with mild cognitive impairment (PD-MCI) and dementia (PDD).
Methods: 53 cognitively normal PD patients (PD-CN), 32 PD-MCI, and 35 PDD underwent concurrent structural MRI (sMRI), diffusion-weighted MRI (dMRI), and [F]FDG PET.
Gestational arsenite exposure alters maternal postpartum heart size and induces Ca-handling dysregulation in cardiomyocytes.
Am J Physiol Heart Circ Physiol
January 2025
Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
Cardiovascular disease is the leading cause of mortality in the US. Studies suggest a role for environmental exposures in the etiology of cardiovascular disease, including exposure to arsenic through drinking water. Arsenic exposure during pregnancy has been shown to have effects on offspring, but few studies have examined impacts on maternal cardiovascular health.
View Article and Find Full Text PDFReplacing native grazers with livestock influences arthropods to have implications for ecosystem functions and disease.
Ecol Appl
January 2025
Centre for Ecological Sciences, Indian Institute of Science, Bengaluru, India.
Grazing by large mammalian herbivores influences ecosystem structure and functions through its impacts on vegetation and soil, as well as by the influence on other animals such as arthropods. As livestock progressively replace native grazers around the world, it is pertinent to ask whether they have comparable influence over arthropods, or not. We use a replicated landscape-level, long-term grazer-exclusion experiment (14 years) to address how ground-dwelling arthropods respond to such a change in grazing regime where livestock replace native grazers in the cold deserts of the Trans-Himalayan ecosystem of northern India.
View Article and Find Full Text PDFCharacteristics of Sciatic Scoliosis in Lumbar Disc Herniation and Comparative Radiographic Outcomes After Treatment With Full-Endoscopic Interlaminar Discectomy.
Asian J Endosc Surg
January 2025
Research Unit, Institute of Orthopedics, Lerdsin Hospital, Department of Orthopaedic Surgery, College of Medicine, Rangsit University, Bangkok, Thailand.
Study Design: Retrospective cohort study.
Background: Sciatic scoliosis is attributed to non-structural scoliosis resulting from the irritation of spinal nerve roots. Although limited research has addressed the specific characteristics of sciatic scoliotic curve patterns, there is a lack of reported data on the pre- and post-radiographic outcomes of patients with sciatic scoliosis caused by lumbar disc herniation who have undergone full-endoscopic interlaminar discectomy (FEID).
Alexidine and Pentamidine Fold Inside the Bowl-Shaped Cavity of p-Sulfonato-calix[4]arene.
Chemistry
January 2025
Institute of Physical Chemistry Polish Academy of Sciences: Polska Akademia Nauk Instytut Chemii Fizycznej, Department IX Photochemistry and Spectroscopy, Kasprzaka 44/52, 01-224, Warsaw, POLAND.
We report on the U-shaped folding of flexible guest molecules of medicinal interest upon their inclusion into macrocyclic cavity of p-sulfonato-calix[4]arene in aqueous media. Alexidine and pentamidine are FDA-approved drug compounds currently rediscovered as potent membrane-targeting antibiotic adjuvants helping restore antibiotic activity against multidrug resistant bacteria pathogens. We have adopted host-guest and crystal engineering approach to study these drugs with a view of potential supramolecular formulations and/or crystal forms.
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