Background: Endovascular procedures and direct surgical clipping are the main therapeutic modalities for managing of BAAs. Furthermore, giant or wide-necked aneurysms and those that involve the PCA or perforators at its neck usually are not embolized.
Case Description: A 55-year-old man presented to the emergency room complaining of sudden and intense headache. Neurological examination evidenced meningismus. Computed tomography disclosed a subarachnoid hemorrhage (Fisher grade III). Arteriograms revealed BAA, whose neck was partially obscured by the PCP. A standard pterional craniotomy was performed, followed by extensive drilling of the greater sphenoid wing. The neck was partially hidden by the PCP, and no proximal control was obtained without drilling the PCP and opening the CS (modified TcA). Drilling of the PCP was begun by cutting the overlying dura and extended caudally as much as possible. Next, opening of the roof of the CS was performed by incising the dura in the oculomotor trigone medial and parallel to the oculomotor nerve and lateral to ICA; the incision progressed posteriorly toward the dorsum sellae. Further resection of the dorsum sellae and clivus was carried out. After performing these steps, proximal control was obtained, aneurysm was deflated, perforators were saved, and aneurysm was clipped.
Conclusions: This study has demonstrated the clinical usefulness of an abbreviated form of the TcA, which led the "modified TcA," in approaching complex low-lying BAA. It provides additional surgical room by removing the PCP and partially opening the CS, which permits further bone removal and improves exposure.
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http://dx.doi.org/10.1016/j.surneu.2008.03.002 | DOI Listing |
JAMA Otolaryngol Head Neck Surg
January 2025
Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Importance: There is a lack of high level of evidence studies comparing the effect of different treatment options for single-sided deafness (SSD).
Objective: To determine the effect of a cochlear implant (CI), bone conduction device (BCD), contralateral routing of signals hearing aid (CROS), and no treatment on speech perception in noise outcomes in patients with SSD.
Design, Setting, And Participants: In this single-center randomized clinical trial, adult patients with SSD were randomized into 3 groups: CI; a trial period with first a BCD on a headband and then a CROS; or a trial period with first a CROS and then a BCD on a headband.
Laryngoscope Investig Otolaryngol
February 2025
Objectives: Hypoglossal nerve stimulation (HGNS) is a promising surgical option for patients with obstructive sleep apnea (OSA) who are intolerant of continuous positive airway pressure therapy (CPAP). Efficacy studies for HGNS stimulation largely focus on the apnea-hypopnea index and/or oxygen desaturation index. This study's objective was to show the physiological effects of HGNS stimulation on upper airway patency, airflow, and treatment effect during polysomnography (PSG) testing.
View Article and Find Full Text PDFActa Pharm Sin B
December 2024
Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Inducing the degradation of KRAS represents a novel strategy to combat cancers with KRAS mutation. In this study, we identify ubiquitin-specific protease 2 (USP2) as a novel deubiquitinating enzyme of KRAS in multiple myeloma (MM). Specifically, we demonstrate that gambogic acid (GA) forms a covalent bond with the cysteine 284 residue of USP2 through an allosteric pocket, inhibiting its deubiquitinating activity.
View Article and Find Full Text PDFJTO Clin Res Rep
January 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Introduction: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UTs) are a recently defined group of aggressive cancers in which the effectiveness of standard treatments for lung cancer is unknown.
Methods: We collected clinical, pathologic, and demographic variables from five institutions for patients whose tumors met criteria for SMARCA4-UTs (undifferentiated phenotype and loss of SMARCA4 (BRG1) by immunohistochemistry).
Results: We identified 92 patients with SMARCA4-UTs; 58 (63%) had stage IV disease at diagnosis and 16 (17%) developed recurrent or metastatic disease after initial diagnosis.
Int Arch Otorhinolaryngol
January 2025
Section of Otolaryngology, Head and Neck Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
Urinary tract infections (UTIs) represent a rare postoperative complication following thyroidectomy. This study aimed to assess the clinicodemographic factors associated with the development of UTIs and subsequent outcomes among patients undergoing thyroidectomy. This retrospective study used the National Surgical Quality Improvement Program (NSQIP) database to analyze patients who underwent thyroidectomy from 2005 to 2019.
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