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Modular comparison of untargeted metabolomics processing steps.
Anal Chim Acta
January 2025
Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Austria; BOKU University, Vienna, Dept. IFA-Tulln, Institute of Bioanalytics and Agro-Metabolomics, Tulln, Austria.
Background: Untargeted metabolomics requires robust and reliable strategies for data processing to extract relevant information form the underlying raw data. Multiple platforms for data processing are available, but the choice of software tool can have an impact on the analysis. This study provides a comprehensive evaluation of four workflows based on commonly used metabolomics software tools: XCMS, Compound Discoverer, MS-DIAL, and MZmine.
View Article and Find Full Text PDFObjective: Recent studies found that recreational legalization of cannabis consumption for Canadian adults has increased presentation to the emergency department (ED) among children. In this descriptive study, our objectives were to (1) understand Canadian pediatric emergency medicine (PEM) providers' training and knowledge of clinical presentations associated with cannabis exposure in children and (2) describe pediatric ED presentations related to cannabis exposure across Canada following legalization in 2018.
Method: In 2021, following ethics board approval, 230 Pediatric Emergency Research Canada (PERC) network pediatric emergency medicine (PEM) physicians were invited to share about their knowledge, training, and experience with patients presenting with cannabis-associated emergencies using an anonymized survey administered through REDCap.
Resection of shrinking secondary thymic cyst during follow-up-a case report.
Mediastinum
July 2024
Department of Radiology, Inje University Sanggye Paik Hospital, Seoul, Korea.
Background: Thymic cysts can be classified as congenital or acquired. Most thymic cysts do not change in size over a short period of time. Although very rare, thymic cyst rupture is associated with serious complications, such as mediastinal hemorrhage and hemothorax.
View Article and Find Full Text PDFImpact of normocapnia vs. mild hypercapnia on prognosis after cardiac arrest: A systematic review and meta-analysis.
Am J Emerg Med
December 2024
Department of Emergency Intensive Care Unit, Yiling Hospital of Yichang, Affiliated Yiling Hospital of China Three Gorges University, Yichang 443002, Hubei Province, China. Electronic address:
Objective: To explore the impact of mild hypercapnia or normocapnia on the prognosis of patients after the return of spontaneous circulation (ROSC) following cardiac arrest (CA).
Methods: This systematic review and meta-analysis followed the guidelines in the PROSPERO report. Information was retrieved in PubMed, Cochrane Library, Embase, and Web of Science to collect all publications in English from January 1, 2000, to March 1, 2024, involving post-CA with mild hypercapnia.
Munchausen Syndrome Presented as Guillain-Barré Syndrome: A Case Report and Literature Review.
Cureus
January 2025
Department of Neurology, Unidade Local de Saúde da Arrábida, Setúbal, PRT.
Munchausen syndrome (MS), a complex form of factitious disorder (FD), presents significant diagnostic and management challenges in emergency and hospital settings. Patients deliberately fabricate or induce symptoms to gain medical attention, often leading to unnecessary interventions, resource misallocation, and iatrogenic harm. This study highlights the diagnostic complexity and the need for multidisciplinary management of Munchausen syndrome through a detailed case report and literature review.
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