AI Article Synopsis
- - The study examined the impact of increased levels of heat shock protein 70 (HSP70) on emotional, learning behaviors, and long-term potentiation in the hippocampus of specially bred mice.
- - HSP70 overexpressing mice performed worse in learning tasks (like shuttle box and 8-arm radial maze) compared to normal mice, while showing no significant differences in anxiety-related behaviors.
- - Despite enhanced long-term potentiation observed in hippocampal slices from these mice, it was suggested that this potentiation could be related to the learning difficulties experienced, indicating a complex link between neural activity and learning performance.
Article Abstract
The effects of inducible heat shock protein 70 (HSP70) on emotional and learning behaviour as well as hippocampal long-term potentiation was investigated in transgenic HSP70 overexpressing mice. In active two-way avoidance learning (shuttle box) as well as spatial 8-arm radial maze learning, the HSP70 overexpressing mice showed diminished learning performance. In several tests there was no indication of differences in anxiety behaviour between transgenic mice and wild-type mice. This suggests that impairment in learning behaviour is unrelated to the learning task and motivational aspects of behaviour. To investigate the neurophysiological correlate of learning, long-term potentiation experiments were performed. In transversal hippocampal slices, an enhanced amplitude of the population spike was found in HSP70 overexpressing mice. It was hypothesised that enhanced potentiation in conjunction with potentiation effects due to learning led to learning impairment.
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| http://dx.doi.org/10.1016/j.nlm.2008.04.006 | DOI Listing |
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