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Antibiotic exposure enriches streptococci carrying resistance genes in periodontitis plaque biofilms.
PeerJ
January 2025
Department of Dental Materials, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Background: Periodontitis is not always satisfactorily treated with conventional scaling and root planing, and adjunctive use of antibiotics is required in clinical practice. Therefore, it is important for clinicians to understand the diversity and the antibiotic resistance of subgingival microbiota when exposed to different antibiotics.
Materials And Methods: In this study, subgingival plaques were collected from 10 periodontitis patients and 11 periodontally healthy volunteers, and their microbiota response to selective pressure of four antibiotics (amoxicillin, metronidazole, clindamycin, and tetracycline) were evaluated through 16S rRNA gene amplicon and metagenomic sequencing analysis.
Presence of Clostridioides difficile on spinach, carrots, cheese and milk in Turkey.
Anaerobe
December 2024
Canakkale Onsekiz Mart University Engineering Faculty Food Engineering, Canakkale, Turkey. Electronic address:
Introduction: The presence of Clostridioides difficile in water, soil, fertilizers, and animal feces suggests the potential existence of C. difficile in foods that come into contact with these sources or become contaminated through indirect means.
Material & Method: A total of 431 samples, consisting of spinach and carrots and raw milk and cheese obtained from cows, goats, buffalo, and sheep, were examined for the presence of C.
A seemingly considerable increase in antimicrobial resistance in the group from blood cultures - the second national study in Denmark.
Infect Dis (Lond)
November 2024
Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
Background: Bacteroides fragilis group species are the most frequently encountered bacteria involved in anaerobic bacteraemia and associated with high mortality rates. In 2012, we performed the first national study of antimicrobial susceptibility in the B. fragilis group from blood cultures in Denmark.
View Article and Find Full Text PDFAnalysis on characteristics and multilocus sequence typing of Clostridium perfringens in western China.
J Antimicrob Chemother
January 2025
Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan 750001, People's Republic of China.
Objectives: The objective of this study was to identify and analyse the distribution characteristics, toxin genotyping and antimicrobial susceptibility of Clostridium perfringens and to investigate its resistance mechanisms and genetic characteristics.
Methods: The MICs of various antibiotics against C. perfringens were determined using the agar dilution method, and resistance genes and toxin genotypes were detected by PCR.
Reevaluating antibiotic prophylaxis: insights from a network meta-analysis on dry socket and surgical site infections.
Evid Based Dent
December 2024
Centre for Biostatistics, School of Health Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Data Sources: Three databases (MEDLINE, Cochrane Library, and Scopus) were searched in December 2021 for 16 Randomised Clinical Trials (RCTs).
Study Selection: Three reviewers reviewed the articles on oral antibiotic prophylaxis (ABP) for the prevention of surgical site infection (SSI) and dry socket (DS) after lower third molar (L3M) extraction using the PICO framework. From 1999 to 2021, RCTs involving healthy patients undergoing L3M extraction with ABP, placebo, or no therapy were included.
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