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Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.
Genes (Basel)
January 2023
Aortic Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
Background: KIF6 (kinesin family member 6), a protein coded by the gene, serves an important intracellular function to transport organelles along microtubules. In a pilot study, we found that a common Trp719Arg variant increased the propensity of thoracic aortic aneurysms (TAA) to suffer dissection (AD). The present study aims for a definite investigation of the predictive ability of 719Arg vis à vis AD.
View Article and Find Full Text PDFPurpose: The purpose of this study was to determine the relationship between Kinesin like protein 6 (KIF6) gene Trp719Arg and major cardiovascular events (MACEs) risk in subjects who received statin therapy.
Methods: PubMed, EmBase, and the Cochrane Library were searched from inception through September 2017. The selected studies evaluated the association of Trp719Arg with MACEs in individuals who received statins.
719Arg Genetic Variant and Risk for Thoracic Aortic Dissection.
Aorta (Stamford)
June 2016
Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.
Background: Carriers of the 719Arg variant in , compared with noncarriers, have been reported to be at greater risk for coronary heart disease (CHD) in six prospective studies. Because CHD, thoracic aortic dissection, and nondissection thoracic aortic aneurysm share some risk factors and aspects of pathophysiology, we investigated whether carriers of the 719Arg variant also have greater odds of thoracic aortic dissection or nondissected thoracic aortic aneurysm than noncarriers.
Methods: We genotyped 140 thoracic aortic dissection cases, 497 nondissection thoracic aortic aneurysm cases, and 275 disease-free controls collected in the United States, Hungary, and Greece and investigated the association between 719Arg carrier status and thoracic aortic dissection, and between 719Arg carrier status and nondissection thoracic aortic aneurysm, using logistic regression models adjusted for age, sex, hypertension, smoking, and country.
Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.
Ann Saudi Med
January 2017
Dr. Cyril Cyrus, University of Dammam, 31441 Saudi Arabia, T: +96613330866,
Background: Kinesin-like protein 6 (KIF6), a member of the kinesin superfamily, is involved in intracellular transport. A few prospective studies have shown the KIF6 variant Trp719Arg (rs20455) to be associated with coronary artery disease (CAD) in Caucasian populations. However, recent genome-wide association studies on CAD have not proven these associations.
View Article and Find Full Text PDFThe Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.
Hereditas
July 2017
Hospital de Alta Especialidad "Juan Graham Casasús", Villahermosa, Tabasco Mexico.
Background: Genetic factors play an important role in the pathogenesis of coronary heart disease (CHD). Kinesin-like protein 6 (KIF6) is a new candidate gene for CHD, since it has been identified as a potential risk factor. The aim of this study was to perform a systematic review and meta-analysis of previously published association studies between the Trp719Arg polymorphism of KIF6 and the development of CHD.
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