AI Article Synopsis
- Thiazolidinediones (TZDs) help manage Type 2 diabetes by improving insulin sensitivity, but have been associated with an increased risk of heart failure (HF).
- There's ongoing debate among healthcare professionals about whether the risk of HF from TZDs is exaggerated, highlighting potential flaws in how HF is defined and assessed.
- The authors call for a reevaluation of HF definitions to improve understanding of the relationship between TZDs and heart failure, which could lead to more informed treatment decisions.
Article Abstract
Evaluation of: Erdmann E, Wilcox RG. Weighing up the cardiovascular benefits of thiazolidinedione therapy: the impact of increased risk of heart failure. Eur. Heart J. 29(1), 12-20 (2008). Thiazolidinediones (TZDs) reduce insulin resistance through the modulation of peroxisome proliferator-activated receptor (PPAR)-gamma activity and are, therefore, used for the treatment of individuals with Type 2 diabetes. TZDs have been blamed for inducing heart failure (HF) and are contraindicated in patients with impaired ventricular function. Whether precipitation of HF by TZDs is overestimated or not remains hotly debated in the scientific community. One message from the TZD-HF debacle is that current definitions of HF lack scientific rigour as they fail to assess cardiac organ function directly using a representative and reliable method. Once cardiologists reappraise and update the current definition of HF, appropriate steps can then be taken to answer the question of whether TZDs really induce true HF.
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| http://dx.doi.org/10.1586/14779072.6.5.623 | DOI Listing |
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