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Desmoid-type Fibromatosis of the Breast: A Case Report.
Ann Ital Chir
March 2025
Breast Surgery Department, General Surgery Center, First Hospital of Jilin University, 130021 Changchun, Jilin, China.
Desmoid-type fibromatosis (DTF) is a rare and locally aggressive benign tumor affecting the breasts. It is characterized by infiltrative growth and local recurrence, though it cannot metastasize. We present the case of a woman in her early 20s diagnosed with a palpable mass within her right breast.
View Article and Find Full Text PDFSurgery of the Primary Tumor in de novo Metastatic Breast Cancer: A Palliative Approach or a Potential Survival Game-Changer?
Ann Ital Chir
March 2025
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Approximately 5-10% of primary breast cancer cases present as de novo stage IV disease, characterized by distant metastases at diagnosis. Traditionally, systemic therapies such as chemotherapy, endocrine therapy and targeted treatments have formed the cornerstone of treatment for metastatic breast cancer (MBC), focusing on disease control, symptom palliation and quality of life improvement. While systemic therapies remain crucial, the role of local treatments, particularly surgery for the primary tumor, is increasingly debated.
View Article and Find Full Text PDFMobile Mammography Utilization and Breast Cancer Screening Adherence Among Medicare Fee-for-Service Beneficiaries.
Clin Breast Cancer
April 2025
American College of Radiology, Harvey L. Neiman Health Policy Institute, Reston, VA.
Introduction: Mobile mammography (MM) can reach women who otherwise would not or could not utilize facility-based mammography (FBM) due to various socioeconomic factors and access barriers. Most literature evaluates individual MM programs and has not explored the potential impact of MM in a large, nationally representative, claims dataset.
Objective: To examine factors associated with MM utilization among female Medicare beneficiaries and whether MM is associated with increased mammography utilization compared use of FBM only.
Effects of Melatonin on the Expression of Invasion-Related Markers (MMP2 and MMP9) in Breast Cancer Cells.
J Cell Biochem
March 2025
Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran.
Breast cancer is one of the most common types of cancer in women, and metastasis is a leading cause of mortality in patients with this disease. This study investigated the effects of melatonin, a natural hormone, on the migration of cancer cells in two cell lines, MCF-7 and MDA-MB-231. MCF-7 and MDA-MB-231 cells were cultured in their respective media.
View Article and Find Full Text PDFThe search for a TNBC vaccine: the guardian vaccine.
Cancer Biol Ther
December 2025
School of Pharmacy, Queen's University Belfast, Belfast, UK.
Nearly 20 million people are diagnosed with cancer each year with breast cancer being the most common among women. Triple negative breast cancer (TNBC), defined by its no/low expression of ER and PR and lack of amplification of HER2, makes up 15-20% of all breast cancer cases. While patients overall have a higher response to chemotherapy, this subgroup is associated with the lowest survival rate indicating significant clinical and molecular heterogeneity demanding alternate treatment options.
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