Aim: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmental colitis associated with diverticular disease (SCAD).
Methods: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years.
Results: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn's disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients.
Conclusion: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712850 | PMC |
| http://dx.doi.org/10.3748/wjg.14.3183 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of Inflammatory Bowel Disease in the Elderly According to Age of Onset.
J Clin Med
December 2024
UGC de Aparato Digestivo, Instituto de Investigación Biomédica de Málaga (IBIMA) Plataforma BIONAD, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
: Elderly populations are under-represented in inflammatory bowel disease (IBD) clinical trials, with limited data on phenotype, treatment patterns, outcomes, and comorbidities. The main objective of this study was to evaluate, in an elderly cohort with IBD, demographic and disease characteristics, comorbidity, polypharmacy, and treatment patterns according to the development of IBD at or before old age. Secondarily, the same analysis was performed based on the type of IBD: ulcerative colitis (UC) or Crohn's disease (CD).
View Article and Find Full Text PDFA study on the causal relationship between the gut microbiome and herpes zoster using Mendelian randomization.
Front Med (Lausanne)
August 2024
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang, China.
Article Synopsis
- The study explores the relationship between herpes zoster (HZ) recurrence and the gut microbiome, finding a potentially bidirectional causal link for the first time.
- It highlights the high global incidence of HZ, which can lead to severe symptoms and is often linked to aging and conditions like inflammatory bowel diseases.
- Utilizing data from large-scale genome studies, the research employs bidirectional Mendelian randomization to clarify how gut bacteria may influence the development of HZ and vice versa.
Wilson's Disease-Crossroads of Genetics, Inflammation and Immunity/Autoimmunity: Clinical and Molecular Issues.
Int J Mol Sci
August 2024
Second Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego Street 9, 02-957 Warsaw, Poland.
Article Synopsis
- Wilson's disease (WD) is a genetic disorder that disrupts copper metabolism, leading to copper overload, potential cell death, and varied clinical symptoms that can appear at any age.
- Immunological abnormalities, including increased IgG and IgM levels and decreased T lymphocyte activity, have been observed in WD patients, highlighting a complex interaction between copper and inflammation.
- Research has identified various autoimmune responses in WD patients, with the presence of autoantibodies occurring independently of treatment type, yet their clinical implications remain unclear.
Sustained Increase in Pediatric Inflammatory Bowel Disease Incidence Across the South West United Kingdom Over the Last 10 Years.
Inflamm Bowel Dis
December 2024
Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, United Kingdom.
Background: Pediatric inflammatory bowel disease (pIBD) incidence has increased over the last 25 years. We aim to report contemporaneous trends across the South West United Kingdom.
Methods: Data were provided from centers covering the South West United Kingdom (Bristol, Oxford, Cardiff, Exeter, and Southampton), with a total area at-risk population (<18 years of age) of 2 947 534.
LONG-HOSP Score: A Novel Predictive Score for Length of Hospital Stay in Acute Lower Gastrointestinal Bleeding - A Multicenter Nationwide Study.
Digestion
December 2023
Department of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan.
Article Synopsis
- A predictive model called the LONG-HOSP score was developed to assess the risk of prolonged hospital stays for patients admitted with acute lower gastrointestinal bleeding (ALGIB), based on their baseline characteristics.
- The study analyzed data from over 8,500 patients across 49 hospitals to create and validate this model, which includes factors such as age, body mass index, and various lab results.
- Findings revealed that certain conditions and treatments during hospitalization, like colitis diagnosis and early colonoscopy, significantly impacted the length of stay, with early interventions helping to reduce it.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!