Background: The goals of breast-conserving surgery are to provide the survival equivalent of mastectomy, a cosmetically acceptable breast and a low rate of locoregional recurrence in the treated breast. This retrospective study investigated the impact of the resection volume on locoregional recurrence after breast-conserving therapy in patients with early-stage invasive breast cancer.
Patients And Methods: Retrospective data from 185 women who were treated for operable breast tumours by breast-conserving surgery between 1995-1999 at the Martin-Luther-University in Halle/Germany were included in our study. Extent of total resection volume (TRV), tumour volume (V) and difference volume (DV) was compared for the influence on locoregional recurrence.
Results: Our data showed no significant correlation between the risk of locoregional recurrence and the extent of resection volume. Predictors of an increased risk of locoregional recurrence after breast-conserving surgery were large primary tumour, grading, lymphatic vascular invasion, hormone receptor status and lack of radiotherapy or hormonal therapy.
Conclusion: According to the accuracy of locoregional disease control and maintenance of the breast's shape, our results support conservative surgery in early-stage breast cancer followed by radiotherapy and adjuvant systemic therapy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
De-escalation of surgical and radiation treatment in elderly luminal breast cancer patients, single institution report and review of the evidence.
World J Surg Oncol
January 2025
Institute of Oncology, Tel Aviv Sourasky Medical Center, Weizmann St 6, Tel Aviv, Israel.
Background: De-intensification of anti-cancer therapy without significantly affecting outcomes is an important goal. Omission of axillary surgery or breast radiation is considered a reasonable option in elderly patients with early-stage breast cancer and good prognostic factors. Data on avoidance of both axillary surgery and radiation therapy (RT) is scarce and inconclusive.
View Article and Find Full Text PDFIntroduction: Locoregional recurrence (LR) is common in locally advanced head and neck cancer (HNSCC), posing challenges for treatment. We analysed outcome parameters and toxicities for patients being treated with radiotherapy (RT) for LR-HNSCC and investigated patient and disease related prognostic factors in this prognostically unfavourable group.
Methods: This analysis includes 101 LR-HNSCC patients treated with RT, radio-chemotherapy (RCT) or radio-immunotherapy (RIT) between 2010 and 2018 at a high-volume tertiary centre.
Constructing individualized follow-up strategies for locally advanced esophageal squamous cell carcinoma patients based on dynamic recurrence risk changes.
Sci Rep
January 2025
Department of Gastrointestinal Surgical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
The aim of this study was to explore the high-risk factors for recurrence in patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing definitive chemoradiotherapy or radiotherapy (dCRT or dRT). Conditional survival (CS) was used to evaluate the dynamic survival and recurrence risk of patients after treatment, and individualized monitoring strategies were developed for patients. Logistic regression analysis was performed to determine independent recurrence risk factors.
View Article and Find Full Text PDFDe-Escalation of Nodal Surgery in Clinically Node-Positive Breast Cancer.
JAMA Surg
January 2025
Breast Unit, Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Importance: Increasing evidence supports the oncologic safety of de-escalating axillary surgery for patients with breast cancer after neoadjuvant chemotherapy (NAC).
Objective: To evaluate the oncologic outcomes of de-escalating axillary surgery among patients with clinically node (cN)-positive breast cancer and patients whose disease became cN negative after NAC (ycN negative).
Design, Setting, And Participants: In the NEOSENTITURK MF-1803 prospective cohort registry trial, patients from 37 centers with cT1-4N1-3M0 disease treated with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) alone or with ypN-negative or ypN-positive disease after NAC were recruited between February 15, 2019, and January 1, 2023, and evaluated.
Single-Port Three-Dimensional Endoscopic-Assisted Axillary Lymph Node Dissection (S-P 3D E-ALND): Surgical Technique and Preliminary Results.
Breast J
January 2025
Department of Surgery, Division of General Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Article Synopsis
- Endoscopic-assisted breast surgery (EABS) offers better cosmetic results for breast cancer patients, but traditional axillary lymph node dissection (ALND) requires larger incisions and more retraction.
- The proposed single-port three-dimensional endoscopic-assisted ALND (S-P 3D E-ALND) uses a minimally invasive technique with high success rates and improved visualization, analyzed from a study of 11 patients.
- Preliminary results show 100% success without open surgery conversion, short operative times, minimal blood loss, and no significant complications over a median follow-up of 7 months, suggesting that S-P 3D E-ALND is a viable alternative for ALND.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!