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Advancements in Vigilance Monitoring: Addressing Fatigue and Sleepiness in Driving.
Sleep
December 2024
Sleep Medicine Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial.
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December 2024
Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Importance: Pediatric patients with cancer commonly experience severely bothersome symptoms. The effectiveness of routine symptom screening with symptom feedback and symptom management care pathways is unknown.
Objective: To determine whether thrice-weekly symptom screening with symptom feedback and management care pathways, compared with usual care, improves overall self-reported symptom scores measured by the Symptom Screening in Pediatrics Tool (SSPedi) in pediatric patients with cancer.
Fatigue in Air Traffic Operations-Opportunities to Enhance Safety.
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Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts.
It's about timing: how density can benefit future research on the optimal dosage of acute physical exercise breaks in esports.
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October 2024
Faculty of Health Sciences Brandenburg, Research Group Degenerative and Chronic Diseases, Movement, University of Potsdam, Potsdam, Germany.
In recent years, organised and competitive video gaming, esports, has gained enormous popularity in many parts of the world, contributing to the growing professionalisation of this sports branch. To become or remain a professional esports player, individuals practice video gaming for several hours a day while remaining in a sitting posture which may not only lead to a decrease in training quality in the short term (eg, due to cognitive fatigue) but also put them at a higher risk for negative health events in the long-term (eg, overuse injuries). Thus, interrupting periods of prolonged video gaming in a sitting posture with acute physical exercise is strongly recommended for esports players even though the optimal dosage of acute physical exercise breaks remains unclear.
View Article and Find Full Text PDFDual Immune Checkpoint Inhibition in Patients With Aggressive Thyroid Carcinoma: A Phase 2 Nonrandomized Clinical Trial.
JAMA Oncol
December 2024
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Importance: Aggressive thyroid carcinoma, including radioiodine refractory (RAIR) differentiated thyroid carcinoma (DTC), medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC), are associated with significant morbidity and mortality and have limited therapeutic options. Distinct immune profiles have been identified in thyroid cancer subtypes suggesting they may be susceptible to immune checkpoint inhibition.
Objective: To evaluate the efficacy of anti-programmed cell death 1 nivolumab and anti-cytotoxic lymphocyte-associated protein 4 ipilimumab in patients with aggressive thyroid carcinoma.
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