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Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404. | LitMetric
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Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404.

Azusa Aoyagi Mariko Ito-Kobayashi Yasunori Ono Yoji Furukawa Mizuki Takahashi Yasunori Muramatsu Megumi Umetani Toshio Takatsu

J Antibiot (Tokyo)

Advanced Technology Research Laboratories, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo, Japan.

Published: March 2008

Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.

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http://dx.doi.org/10.1038/ja.2008.122DOI Listing

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