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Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases.
J Neuroinflammation
January 2025
Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within the central nervous system (CNS) can regulate energy metabolism to generate or degrade LDs in response to diverse pathological stimuli. This article provides a comprehensive review on the composition of LDs in CNS, their generation and degradation processes, their interaction mechanisms with mitochondria, the distribution among different cell types, and the roles played by these cells-particularly microglia and astrocytes-in various prevalent neurological disorders.
View Article and Find Full Text PDFThe implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh.
Harm Reduct J
January 2025
Salvation Army Centre for Addiction Services and Research, University of Stirling, Stirling, Scotland.
Background: Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country. In response to concerns about drug-related harms in Edinburgh, elected officials have considered introducing SDCFs in the city. This paper presents key findings from a feasibility study commissioned by City of Edinburgh Council to support these deliberations.
View Article and Find Full Text PDFEvaluating the bioavailability of rare earth elements in paddy soils and their uptake in rice grains for human health risk.
Environ Geochem Health
January 2025
Department of Agricultural Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Rare earth elements (REEs) are a critical global focus due to their increasing use, raising concerns about their environmental distribution and human exposure, both vital to food safety and human health. Surface soil (0-30 cm) and corresponding rice grain samples (n = 85) were collected from paddy fields in Taiwan. This study investigated the total REE contents in soil through aqua regia digestion, as well as their labile forms extracted using 0.
View Article and Find Full Text PDFPhotocatalytic removal of textile wastewater-originated methylene blue and malachite green dyes using spent black tea extract-coated silver nanoparticles.
Sci Rep
January 2025
Department of Food and Nutrition Sciences, College of Agricultural and Food Sciences, King Faisal University, Al Ahsa, 31982, Saudi Arabia.
The spent black tea extract was utilized in order to synthesize the spent black tea silver nanoparticles (SBT-AgNPs). Various parameters were tested to yield the best production of SBT-AgNPs. The characterization was conducted by X-Ray diffraction, Scanning electron microscopy, Zeta potential and energy dispersive X-ray (EDX).
View Article and Find Full Text PDFHigh interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test.
NPJ Biofilms Microbiomes
January 2025
Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and School of Medicine, Tzu Chi University, Hualien, Taiwan.
Indoxyl sulfate (IS) has been implicated in the pathogenesis of cardiovascular diseases. IS is converted from indole, a metabolite of dietary tryptophan through the action of gut microbial tryptophanase, by two hepatic enzymes: CYP2E1 and SULT1A1. We hypothesized that the effect of tryptophan intake on IS production might differ from person to person.
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